In trying to overcome RNAi’s delivery hurdle, many researchers are experimenting with viral vectors, liposomal formulations, hydrodynamic administration, and the like. But one privately held company, Cyntellect, has taken a different tack: the company’s platform uses lasers to temporarily permeablize cells for transfection. Although the technology is not commercially available, Cyntellect has already signed several deals to pilot test the technology for interested parties, one of which is to purchase a prototype of the platform this year.
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