Data Suggests RNAi May Be Used to Fight
Mad Cow, Other Prion Diseases in Livestock

Researchers this week published data in the Proceedings of the National Academy of Sciences suggesting that RNAi might be used to produce transgenic livestock resistant to prion disease such as bovine spongiform encepholopathy.

According to the PNAS paper, the researchers designed short hairpin RNAs that suppress caprine and bovine prion protein (PrP). Lentiviral vectors were used to deliver a transgene expressing the shRNAs into goat fibroblasts.

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Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.

Nov
05
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Sophia Genetics

With the Next Generation Sequencing (NGS), genomes sequencing has been democratized over the last decades with the detection of genomic alterations, thus replacing Sanger sequencing.