By Doug Macron

When Pfizer pulled back from a commitment to file an investigational new drug application on an RNAi candidate next year, it joined a small but growing list of big pharmas that have ostensibly run into difficulties developing the gene-silencing technology for therapeutic applications.

At the same time, a handful of RNAi drug shops have found forging alliances with pharmaceutical firms to be challenging, in some cases and on several occasions missing previous partnership guidance.

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