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Bioo Scientific, Qiagen

Bioo Scientific has recently introduced the RNA-Lancer II, a delivery agent for in vivo RNAi research.
According to the company, the product uses a set of neutral hydrophobic molecules to encapsulate and deliver RNAi agents into tissues for both target validation and therapeutic development applications.

Qiagen has launched miScript miRNA mimics and miScript miRNA inhibitors.
According to the company, the products come ready-to-transfect for use in gene regulation and cellular pathway analysis.
The miRNA mimics are synthetic RNA oligonucleotides that function like mature endogenous miRNA molecules when transfected in to mammalian cells and can be used to artificially up-regulate the level of any miRNA in a cell.
The inhibitors are synthetic chemically modified RNA oligonucleotides that inhibit endogenously expressed miRNAs. miRNA Inhibitors effectively lower the endogenous levels of miRNA in cells enabling loss-of-function studies.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.