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Asuragen Gets USPTO Nod on Claims for Use of miRNAs in Gene-Expression Analysis

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Asuragen said last week that it has received a notice of allowance from the US Patent and Trademark Office for a patent application related to the use of microRNAs as normalizers in gene-expression studies.

“Data normalization is necessary to control for sample variability that can adversely affect the accurate quantification of gene expression,” the company said. “Improper normalization can affect the magnitude and even the direction of change in miRNA gene expression in diseased clinical samples, such as tumor specimens, and is critical for the development of robust and reliable research and diagnostic assays.

Asuragen said that studies have validated the use of the use of “numerous different endogenous miRNAs for normalization with a variety of tissue and sample types,” which are particularly useful for gene-expression measurement techniques employing RT-qPCR.

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