Skip to main content
Premium Trial:

Request an Annual Quote

Arrowhead Picks Up Drug-Delivery Technology through Alvos Acquisition


Arrowhead Research said this week that it has expanded its portfolio of drug-delivery technologies through the acquisition of privately held Alvos Therapeutics for roughly $2.1 million in stock.

According to Arrowhead, Alvos has rights to a platform of proprietary human-derived homing peptides developed by the MD Anderson Cancer Center. These targeting agents can be linked to siRNAs and small molecules to carry drugs to target cells.

Arrowhead said it plans to use the peptide technology to enhance its Rondel and dynamic polyconjugate siRNA delivery approaches.

Under the terms of the acquisition, Arrowhead bought all outstanding shares of Alvos in exchange for 315,467 shares of restricted common stock. Arrowhead's shares were trading around $6.68 midweek.

In addition, Alvos stockholders are eligible to receive additional Arrowhead stock valued at up to $23.5 million based on the achievement of clinical and regulatory milestones, including the demonstration of statistically significant efficacy in clinical trials, Arrowhead said.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.