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Ambion, Mirus Bio, DNA 2.0

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Ambion has recently introduced Pre-miR miRNA precursor molecules.

The molecules are chemically modified and optimized nucleic acids designed to mimic the microRNA molecules in cells, the company said. They are designed to directly enter into the miRNA processing pathway, and "are treated identically to endogenous miRNA within the cell. Since the … molecules directly enter the miRNA pathway, they eliminate any non-miRNA cellular response that is seen with siRNA-like designs."

The molecules "will enable miRNA functional analysis for up-regulation of miRNA activity," Ambion added.

Additional details about the molecules can be found at http://www.ambion.com/catalog/CatNum.php?17110.


Mirus Bio has recently launched an online store.

According to the company, all its research reagent products are now available for purchase on the web. Additional details can be found at https://www.mirusbiocorporation.com.


DNA 2.0 recently introduced RNAissance genes, a collection of about 20,000 human genes resistant to RNAi.

According to the company, the synthetic genes are "designed to trans-complement the RNAi knocked out activity from the natural human sequences in order to validate functional pathways postulated by RNAi experiments.

The genes' nucleotide sequences, DNA 2.0 said, share only between 60 and 75 percent identity with the original human gene, and therefore are not recognized by siRNA-complexes targeted towards the endogenous gene. "RNAissance genes will thus restore normal gene function in the presence of siRNA that silences the chromosomal copies," the company added.

Details about the genes can be found at http://www.planetgene.com/commerce.

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