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Alnylam UT Southwestern Researchers Publish Data on agRNAs

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Alnylam Pharmaceuticals last week reported the publication of data in collaboration with researchers from the University of Texas Southwestern Medical Center showing a novel mechanism of gene expression regulation by anti-gene RNAs.

According to the company, agRNAs are dsRNAs that target non-coding RNA sequences, and can act as either inhibitors or activators of gene expression.

They were previously shown to be complementary to non-coding transcripts that span the promoter region of genes, Alnylam said. The new research, which appeared in Nature Chemical Biology, demonstrates that agRNAs that target non-coding RNAs corresponding to regions beyond the 3' termini of genes can also silence or activate genes in a sequence-specific manner.

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