Alnylam Pharmaceuticals announced last week that it has initiated a phase I study of its siRNA-based liver cancer therapy ALN-VSP.

The study, the company said, will enroll an estimated 55 patients with advanced liver cancers, including hepatocellular carcinoma and other solid tumors with liver involvement, who are refractory to the standard of care.

The study is designed to evaluate the intravenous drug's safety, tolerability, pharmacokinetics, and pharmacodynamics.

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