Skip to main content
Premium Trial:

Request an Annual Quote

Alnylam Says European RNAi Patent Invalidated

NEW YORK (GenomeWeb News) - Alnylam Pharmaceuticals this week announced that the European Patent Office has overturned the claims of one of its patents covering compositions, methods, and uses of siRNAs between 15 and 49 nucleotides long.

The patent in question, EP 1214945, is part of Alnylam's so-called Kreutzer-Limmer patent estate, which the company acquired when it bought German RNAi shop Ribopharma in 2003.

According to Alnylam, the ruling is not final and can be appealed. Additionally, the ruling does not affect other patents within the Kreutzer-Limmer intellectual property estate.

"We strongly believe in the inventive matter described in the '945 patent and we intend to take the next step and appeal the decision made today through the EPO's appeal process," Alnylam President and COO Barry Greene said in a statement.

In 2006, the EPO upheld the validity of another patent in the Kreutzer-Limmer family, but only after Alnylam amended its claims.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.