Alnylam Reports Positive Phase I Data on ATTR Drug; Sees Pfizer Drug Setback as FDA Guide | GenomeWeb

Alnylam Pharmaceuticals this week released positive phase I data on its investigational TTR-mediated amyloidosis treatment ALN-TTR02, reporting that the drug triggered up to 94 percent reductions in levels of its target protein after a single dose.

The effects were also found to be rapid, dose-dependent, and durable, putting Alnylam on track to begin a phase III pivotal trial of the drug should data from a recently initiated phase II study prove positive, CMO Akshay Vaishnaw said during a conference call.

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