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Alnylam Releases Data Showing siRNAs Can Block Infection in CHO Cells


Alnylam Pharmaceuticals this week reported data showing that siRNAs designed to target a virus known to infect Chinese hamster ovary cells, which are used to produce recombinant proteins and monoclonal antibodies, can inhibit infection and viral replication.

In the work, siRNAs were designed and synthesized toward vesivirus, a virus that can infect CHO cells and cause "adverse effects on product quality and/or potential interruption in biologics manufacturing and product supply," the company said. CHO cells grown in suspension culture were infected with vesivirus and then treated with the siRNAs.

"The siRNA treatment was found to potently block viral replication with an approximate 2-log reduction in vesivirus RNA, as measured by PCR," Alnylam noted, adding that the results provide "key proof of concept for applications of RNAi technologies as an antiviral strategy in biologics manufacturing."

About a year ago, Alnylam announced that it established a new initiative, dubbed Alnylam Biotherapeutics, to use its RNAi know-how to improve biologics manufacturing (GSN 11/9/2009).

The Scan

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The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says.

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New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs.

Offer to Come Back

The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back.

PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication

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