A little more than seven months after Alnylam Pharmaceuticals became the first firm to partner with a big pharma player on RNAi drug development, the company is first again — this time in launching an initial public offering.

Alnylam said last weekend that it has filed with the US Securities and Exchange Commission to float its shares on the NASDAQ under the ticker symbol “ALNY” in an IPO worth up to roughly $86.3 million. The announcement was made concurrently with the release of a preliminary prospectus for the IPO.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.