Alnylam Pharmaceuticals this week presented preclinical data on its investigational treatment for alpha-1 antitrypsin deficiency-associated liver disorders.

AAT is a liver-produced serine proteinase inhibitor that protects the lungs from neutrophil elastase and other irritants that cause inflammation, according to Alnylam. In the liver, misfolding of the mutant form of the protein disrupts its normal release into the blood, causing it to aggregate in hepatocytes. The result can be liver injury, fibrosis, cirrhosis, and liver cancer.

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Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

Yale Environment 360 writes that synthetic and conservation biologists aren't always on the same wavelength, but they are trying to reach an understanding.

In Science this week: full CRISPR locus integration complex structure, and more.