Alnylam Pharmaceuticals this week released final data from a phase I study of its TTR-mediated amyloidosis drug ALN-TTR01, which showed the compound triggered dose-dependent and durable reductions in target protein levels.

ALN-TTR01 comprises siRNAs against transthyretin, or TTR. Alnylam previously stated that it intends to advance a different version of the drug called ALN-TTR02, which uses a second-generation lipid delivery vehicle and is in phase I testing, to the market.

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