Alnylam Pharmaceuticals announced this week that it has filed with UK regulators to begin phase I testing of a subcutaneous version of its TTR-mediated amyloidosis treatment called ALN-TTRsc.

Currently, Alnylam is testing an intravenously delivered form of the drug called ALN-TTR02, which it anticipates entering phase III testing by the end of this year. However, the firm has long been planning to incorporate its GalNAc conjugate delivery technology into its TTR amyloidosis program.

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