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Alnylam Data Shows 'Majority' of Patients in Liver Cancer Extension Study Have Stable Disease


Alnylam Pharmaceuticals this week announced data from a phase I extension study of its RNAi-based liver cancer therapy ALN-VSP, which showed the drug could control disease for more than six months in the majority of patients treated.

The findings include a complete response from an endometrial cancer patient with multiple liver metastases.

The extension study enrolled patients from a previous phase I trial who achieved stable disease after four months or longer of ALN-VSP treatment. Main objectives included continued evaluation of safety and tolerability and assessment of disease response.

Alnylam previously announced that it would only advance ALN-VSP into phase II testing with a partner, and that it expected to forge such a deal this year (GSN 5/10/2012).