Alnylam Pharmaceuticals last week published preclinical data describing the development of a dendritic cell cancer vaccine enhanced with RNAi.

According to the company, its researchers and collaborators from Radboud University Nijmegen Medical Centre designed siRNAs toward PD-L1 and PD-L2, which are “key co-inhibitory proteins expressed on antigen-presenting cells that strongly limit activation of T-cells needed for a potent immune response to the tumor.”

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