Skip to main content
Premium Trial:

Request an Annual Quote

Alnylam Adds Preeclampsia Drug to Pipeline

Premium

NEW YORK (GenomeWeb) – Alnylam Pharmaceuticals this month announced that it has expanded its pipeline to include ALN-AGT, a subcutaneously administered treatment for preeclampsia and other pregnancy-associated hypertensive disorders.

The drug is designed to silence angiotensinogen, the protein precursor for a peptide hormone called angiotensin II that promotes vasoconstriction as part of the renin-angiotensin system. It is delivered subcutaneously using Alnylam's GalNAc conjugates.

According to Alnylam, gain-of-function human mutations or variants of AGT are associated with increased risk of hypertension — a hallmark of preeclampsia — in pregnant women. However, small-molecule inhibitors of the renin-angiotensin system cross the placental barrier and are associated with fetal toxicity, preventing their therapeutic use.

Earlier this year, the company and academic collaborators presented rodent data in a preeclampsia model showing that ALN-AGT could knock down maternal AGT in the liver without affecting the fetus, significantly improve pregnancy-related hypertension, ameliorate preeclamptic sequelae such as proteinuria in the mother, and improve fetal outcomes.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.