Alnylam Pharmaceuticals this week provided an update to its research and development activities, adding a new preclinical program to its pipeline with ALN-AS1 for acute intermittent porphyria while dropping its refractory anemia drug ALN-HPN in order to focus on “higher priority” efforts.

Notably, the ALN-AS1 program will take advantage of Alnylam's GalNAc conjugate liver-delivery strategy, reflecting the company's growing focus on conjugates, which CEO John Maraganore described in 2011 as “the future for delivery of small interfering RNAs.”

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Researchers report that deleting one gene from butterflies affects their wing coloration patterns, according to the Washington Post.

The Seattle Times writes that pharmacogenomics testing can help choose medications that may work best for people with depression.

In PNAS this week: genome sequencing of weevil symbionts, retinoid X receptor deletion in lung cancer metastasis, and more.

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