By Molika Ashford

Purification steps can remove the confounding influence of cell-based miRNAs, allowing more robust measurement of circulating miRNAs, Affymetrix researchers reported recently in a study in PLoS One.

Using the company's GeneChip miRNA microarray, the team evaluated a variety of methods to reduce the presence of cellular miRNAs in blood samples in order to allow more accurate and reproducible analysis of circulating miRNA for potential predictive signatures.

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