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UK Biobank Study Investigates Incomplete Penetrance of Mendelian Disease Variants

The study, presented at the virtual ASHG annual meeting this week, analyzed phenotypes in carriers of different recessive Mendelian diseases.

MSK Fellows Develop Online Resource to Increase Awareness of Genetic Cascade Testing

They hope the website will be an unbiased source for genetic risk information, testing, and financial support services and spur cascade testing in families.

Cepheid Sees High Demand for Respiratory Tests Through Remainder of 2021

After shipping 16 million respiratory test cartridges in the third quarter, the firm forecasts another 16 million tests to be sold in the final quarter of 2021.

Guidelines for Ancient DNA Work

More than two dozen researchers have developed new ethical guidelines for conducting ancient DNA research, which they present in Nature.

Guardant Health: Myrtle Potter

Member for

9 months
Submitted by molika.ashford… on Thu, 10/21/2021 - 12:37

Guardant Health has appointed Myrtle Potter to serve on its board of directors. Potter is the CEO of Sumitovant Biopharma, the parent company of five biotechnology subsidiaries. Prior to that, she worked at Roivant Sciences and as CEO of Myrtle Potter & Company. From 2000 to 2004, Potter was the COO at Genentech, having previous served as president of commercial operations and executive VP at the company. Prior to joining Genentech, she held various positions, including at Bristol-Myers Squibb, and Merck.

And Cleared

A UK regulator has cleared former UK Prime Minister David Cameron in concerns he should have registered as a consultant-lobbyist for his work with Illumina, according to the Financial Times.

Suit Over Allegations

The Boston Globe reports that David Sabatini, who was placed on leave from MIT after allegations of sexual harassment, is suing his accuser, the Whitehead Institute, and the institute's director.

Nature Papers on Esophageal Cancer, Origin of Modern Horses, Exome Sequencing of UK Biobank Participants

In Nature this week: genetic and environmental influences of esophageal cancer, domestic horse origin traced to Western Eurasian steppes, and more.

Associate Research Scientist/Research Scientist

 

Associate Research Scientist/Research Scientist

                       

The Herbert and Florence Irving Institute for Cancer Dynamics of Columbia University (IICD, https://cancerdynamics.columbia.edu) invites applications for Associate Research Scientist or Research Scientist positions in quantitative aspects of cancer research.

The IICD is an interdisciplinary institute located on the Morningside Heights campus of Columbia University, focused on the interplay between mathematical sciences and cancer research. We collaborate across disciplinary boundaries to develop aspects of science and engineering that can improve our understanding of cancer biology, origins, treatment and prevention.

The IICD invites applications from researchers who have strong research expertise in AI, machine learning and related statistical methods, and their application to any aspect of cancer research, including, but not limited to, early detection, cancer immunology, single cell technologies, and imaging.

 

To this end, we expect successful candidates to:

- Conduct independent, cutting-edge research in cancer data science (75% effort)

- Support the mission of the Institute on developing the interplay between mathematical sciences and cancer research, through contributions to outreach and training (15% effort)

- Identify and attract external funding to support their research program (10% effort)

 

The IICD offers a competitive salary and an inclusive, interdisciplinary environment that promotes professional and personal development of the Institute’s members.  All research scientists may benefit from additional training opportunities available at the Morningside campus and the Herbert Irving Comprehensive Cancer Center. IICD also provides administrative support for grant submissions and development of collaborative research.

 

Candidates are expected to have a PhD in a quantitative discipline such as statistics or computer science, or in medicine, biology or another STEM discipline with a strong quantitative component. STEM graduates who wish to complete their transition towards computational biology are strongly encouraged to apply for the Associate Research Scientist position.   Candidates for Associate Research Scientist are strongly encouraged, but not required to have postdoctoral experience. Candidates for Research Scientist should have made substantial contributions in their field and have experience in collaborative research and in training students, postdocs or researchers.

 

Minimum Qualifications

- PhD in a quantitative discipline such as statistics or computer science, or in medicine, biology or another STEM discipline with a strong quantitative component 

- Strong analytical, computational, and quantitative skills

- A record of outstanding research, commensurate with years of professional experience, as evidenced by

      publications, grants, software outputs, and other measures of impact.

 

Additional Information  

Candidates for professional officer of research positions are expected to have established their ability to conduct original, independent scientific research. To hold the rank of research scientist, a candidate’s qualifications and contributions to their fields of research must be equivalent to those of an associate professor; for the rank of associate research scientist, to those of an assistant professor. All candidates for Professional Officer of Research positions are expected to be able to work well in teams and to communicate effectively the results of their research or research activities both orally and in writing.

 

Application: https://academic.careers.columbia.edu/#/85052

Organization
Columbia - Irving institute for Cancer Dynamics
Job Location

1190 Amsterdam ave
suite 601 mail code: 5860
New York, NY 10027
United States

Salary
Competative
Requirements

Candidates are expected to have a PhD in a quantitative discipline such as statistics or computer science, or in medicine, biology or another STEM discipline with a strong quantitative component. STEM graduates who wish to complete their transition towards computational biology are strongly encouraged to apply for the Associate Research Scientist position.   Candidates for Associate Research Scientist are strongly encouraged, but not required to have postdoctoral experience. Candidates for Research Scientist should have made substantial contributions in their field and have experience in collaborative research and in training students, postdocs or researchers.

 

Minimum Qualifications

- PhD in a quantitative discipline such as statistics or computer science, or in medicine, biology or another STEM discipline with a strong quantitative component 

- Strong analytical, computational, and quantitative skills

- A record of outstanding research, commensurate with years of professional experience, as evidenced by

      publications, grants, software outputs, and other measures of impact.

About Our Organization

The Herbert and Florence Irving Institute for Cancer Dynamics (IICD) is an interdisciplinary institute located on the Morningside Heights campus of Columbia University and focused on the interplay between mathematical sciences and cancer research, collaborating across disciplinary boundaries to develop aspects of science, engineering and the humanities that can improve understanding of cancer biology, origins, treatment and prevention. The IICD also maintains strong connections to members of the Herbert Irving Comprehensive Cancer Center at the Columbia University Irving Medical Center.

The Institute focuses on understanding the dynamics of cancer at different scales, from cells to patients to populations. Among our cancer research interests are tumor evolution, computational ‘omics, immunology and metabolism. We work on technologies for molecular annotation of tumors in three dimensions at single cell resolution. Our work is underpinned by strong statistical and data science research, including stochastic computation, bioinformatics and causal inference.

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Associate Research Scientist

Associate Research Scientist

 

The Herbert and Florence Irving Institute for Cancer Dynamics at Columbia University (IICD, https://cancerdynamics.columbia.edu) invites applications for Associate Research Scientist positions in the mathematical sciences, with a particular emphasis on research relating to cancer.

 

The IICD is an interdisciplinary institute located on the Morningside Heights campus of Columbia University and focused on the interplay between mathematics and cancer research, collaborating across disciplinary boundaries to develop tools and methods that can improve our understanding of cancer biology, origins, evolution, treatment and prevention.

The IICD invites applications from researchers who have strong research expertise using and developing mathematical and computational methods for data analysis that can contribute to any aspect of cancer research. Areas of interest include, but are not limited to, systems biology, mathematical immunology, models for tumor growth and metastasis, mathematical population genetics, phylogenetics, computer vision, machine learning, geometric and topological data analysis, probability theory and statistics.

 

To this end, we expect successful candidates to:

- Conduct independent, cutting-edge research (75% effort)

- Support the mission of the Institute on developing the interplay between mathematical sciences and cancer research, through contributions to outreach and training (15% effort)

- Identify and attract external funding to support their research program (10% effort)

 

The IICD offers a competitive salary and an inclusive, interdisciplinary environment that promotes professional and personal development of the Institute’s members.  All research scientists may benefit from additional training opportunities available at the Morningside campus and the Herbert Irving Comprehensive Cancer Center. IICD also provides administrative support for grant submissions and development of collaborative research.

 

Candidates are expected to have a PhD in mathematics, statistics or computer science, or another STEM discipline with a strong quantitative component. STEM graduates who wish to complete their transition towards mathematical biology are strongly encouraged to apply.  Candidates for Associate Research Scientist are strongly encouraged, but not required to have postdoctoral experience, but they must have a doctorate by the time they are appointed.

           

Minimum Qualifications

-Ph.D.             

- Strong knowledge of statistics, probability or machine learning for data analysis

- A record of outstanding research, commensurate with years of professional experience, as evidenced by

      publications, grants, software outputs, and other measures of impact.

 

Additional Information          

Candidates for Professional Officer of Research positions are expected to have established their ability to conduct original, independent scientific research. To hold the associate research scientist rank, candidates’ qualifications and contributions to their fields of research must be equivalent to those of an assistant professor. All candidates for all Professional Officer of Research positions are expected to be able to work well in teams and to communicate effectively the results of their research or research activities both orally and in writing.

 

Application: https://academic.careers.columbia.edu/#/84326

Organization
Columbia - Irving institute for Cancer Dynamics
Job Location

1190 Amsterdam ave
suite 601 mail code: 5860
New York, NY 10027
United States

Salary
Competative
Requirements

Candidates are expected to have a PhD in mathematics, statistics or computer science, or another STEM discipline with a strong quantitative component. STEM graduates who wish to complete their transition towards mathematical biology are strongly encouraged to apply.  Candidates for Associate Research Scientist are strongly encouraged, but not required to have postdoctoral experience, but they must have a doctorate by the time they are appointed.

           

Minimum Qualifications

-Ph.D.             

- Strong knowledge of statistics, probability or machine learning for data analysis

- A record of outstanding research, commensurate with years of professional experience, as evidenced by

      publications, grants, software outputs, and other measures of impact.

About Our Organization

The Herbert and Florence Irving Institute for Cancer Dynamics (IICD) is an interdisciplinary institute located on the Morningside Heights campus of Columbia University and focused on the interplay between mathematical sciences and cancer research, collaborating across disciplinary boundaries to develop aspects of science, engineering and the humanities that can improve understanding of cancer biology, origins, treatment and prevention. The IICD also maintains strong connections to members of the Herbert Irving Comprehensive Cancer Center at the Columbia University Irving Medical Center.

The Institute focuses on understanding the dynamics of cancer at different scales, from cells to patients to populations. Among our cancer research interests are tumor evolution, computational ‘omics, immunology and metabolism. We work on technologies for molecular annotation of tumors in three dimensions at single cell resolution. Our work is underpinned by strong statistical and data science research, including stochastic computation, bioinformatics and causal inference.

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PhD and MS Graduate Assistantships

PhD and MS positions in Ecosystem Ecology are available in the Center for Ecosystem Science and Society (Ecoss) at Northern Arizona University.

 

The Ecoss mission is to conduct high-impact, innovative research on ecosystems and how they respond to and shape environmental change, to train next-gen scientists, and to communicate discovery and its relevance to people. Much of our work in microbial ecology uses genomics and a technique we developed called quantitative stable isotope probing, ideal for measuring rates of microbial processes in the wild.

Graduate student benefits include stipend (TA or RA), tuition waiver, and health insurance.

Candidates should explore the Ecoss website (ecoss.nau.edu) and contact the professor whose interests align most closely.

Prospective students should directly communicate with an Ecoss faculty member before submitting an application. Although applications are officially due in the Department of Biological Sciences by January 15, 2022, we encourage applicants to submit prior to December 1, 2021 for possible consideration for a prestigious NAU Presidential Fellowship. When contacting an Ecoss faculty member, please include a description of your background, research interests and qualifications, as well as a current resume or curriculum vitae. Please consult the list of faculty to determine who is accepting new students for the 2022-23 academic year.

Ecoss is committed to fostering a diverse and inclusive workplace (ecoss.nau.edu/inclusion/). We strongly encourage applications from women and members of underrepresented minority groups.

How microorganisms regulate biogeochemical responses of ecosystems to environmental change, using tools in quantitative ecology and molecular biology (next-gen sequencing, bioinformatics, quantitative stable isotope probing). Bruce Hungate, Paul Dijkstra, Ben Koch, & Egbert Schwartz ([email protected], [email protected], [email protected], [email protected])

Freshwater ecology, including the science of river restoration and dam removal, terrestrial aquatic interactions, microbial ecology and bioinformatics, and food web ecology. Jane Marks & Ben Koch ([email protected], [email protected])

 

Data-driven modeling and forecasting to understand carbon and nitrogen cycle response to global change at ecosystem, regional, and global scales. Ecoinformatics focus. Yiqi Luo & Deborah Huntzinger ([email protected], [email protected])

 

Habitat restoration, invasions, and climate change through a number of lenses: plant-soil interactions, drought adaptation, pollinators, and soil microbial communities.  Karen Haubensak ([email protected])

 

The impact of climate change on Alaskan ecosystems, including effects of changing fire and permafrost on plants, soils, and ecosystem services. Michelle Mack, Ted Schuur, & Xanthe Walker ([email protected], [email protected], [email protected])

 

Plant and microbial ecophysiology exploring the interaction of water and carbon metabolism in diverse systems, from the world's tallest trees to soil microorganisms. George Koch ([email protected])

 

Terrestrial ecosystems and global change: above and below ground processes, plant carbon allocation, biosphere-atmosphere interactions and feedbacks, radiocarbon, and phenology. Mariah Carbone & Andrew Richardson ([email protected], [email protected])

 

Functional diversity of plant communities, including community assembly processes and impacts of diversity on ecosystem structure and function, primarily in dryland biomes. Brad Butterfield ([email protected]). Dr. Butterfield is not accepting new students for the 2022-23 academic year.

 

Organization
Center for Ecosystem Science and Society, Northern Arizona University
Organization Website
Job Location

Biology Box 5640
Northern Arizona University
Flagstaff, AZ 86011
United States

How to Apply

Prospective students should directly communicate with an Ecoss faculty member before submitting an application. Although applications are officially due in the Department of Biological Sciences by January 15, 2022, we encourage applicants to submit prior to December 1, 2021 for possible consideration for a prestigious NAU Presidential Fellowship. When contacting an Ecoss faculty member, please include a description of your background, research interests and qualifications, as well as a current resume or curriculum vitae. Please consult the list of faculty to determine who is accepting new students for the 2022-23 academic year.

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Software Test Engineer

We are seeking a Software Test Engineer to support and extend the capabilities of the BioXp family of products, this person is responsible for evaluating software functions, designing test protocols and unit tests to ensure that products work as intended, and completing all testing procedures, suggesting performance changes, and preparing performance reports. A successful candidate will have an enthusiastic entrepreneurial work ethic. This person will work closely with Software Developer, Product Development and Research Scientists as well as Device Manufacturing.  

 

Essential Duties and Responsibilities:

  • Meeting with stake holders to discuss software specifications and controls.
  • Using the software as intended to control instrument and analyze its functional properties.
  • Designing manual and automated test procedures to evaluate each instrument control software product in c#.
  • Building, coding, and implementing software evaluation test programs.
  • Running test programs to ensure that testing protocols evaluate the software correctly.
  • Perform function test on controlled instrument to ensure that the software functions correctly.
  • Tweaking the software testing systems for maximum performance.
  • Finalizing and documenting testing procedures.
  • Completing final tests and creating test reports.
  • Presenting test reports to management and suggesting software fixes.
  • Utilize standard Software Lifecycle Management tools and techniques as well as development tools JIRA / Confluence/ Agile / SCRUM.   
  • Review product and/or application information including manuals and brochures for technical accuracy.
  • Experience with GMP and Software Design Controls plus
  • Experience with windows desktop application in C# WPF, Prism and MVVM is required
  • All other duties as assigned or necessary

     

    Working Conditions:

    • Under standard working conditions, this position is based in our San Diego, CA office. 
    • Prolonged periods of sitting at a desk and working on a computer.
    • As a critical and essential role, the candidate must be willing and able to travel to the San Diego, CA office to report to work.  We have protocols in place to provide a safe, socially distanced work environment.
    • Ability to lift up to 20 pounds required.
    Organization
    Codex DNA
    Organization Website
    Job Location

    9535 Waples St Suite 100
    San Diego, CA 92121
    United States

    Requirements

    Required Qualifications:

    • 5+ years of working experience with software or system verification.
    • 3+ years’ experience using Microsoft .NET Frameworks, C# WPF, Prism.
    • 5+ years of experience in designing or architecting automated tests & framework such as MSTest, Ranorex or Selenium.
    • Ability to collate data and compile test reports.
    • Excellent software troubleshooting skills.
    • Ability to design and write complex software testing procedures.
    • 5+ years relevant engineering experience or equivalent.
    • Highly adaptable and independent
    • Thrive in a start-up, rapidly growing company environment
    • Excellent verbal and writing skills, great computer skills
    • Take initiative and have a growth mindset
    • Follow direction with enthusiasm

     

    Education Requirements:

    • B.S./M.S. in Computer Science or significant experience.
    About Our Organization

    Our mission is to apply our breakthroughs in automation solutions for DNA, RNA, and protein synthesis to enable customers to program and "write" synthetic biology that creates sustainable healthcare and technology solutions for some of humanity’s biggest challenges.  Our gene synthesis portfolio reduces the turnaround time for synthesizing workflows from weeks and months to days and hours, and includes the BioXp™ system, DNA services, Gibson Assembly® reagents, and Vmax™ chemically competent cells.  In addition to automating, accelerating, and optimizing DNA design, synthesis, cloning and amplification, Codex DNA and the BioXp™ system ensure your designs stay in your hands, marrying speed and security for innovators in drug discovery, vaccine development, precision medicine, and beyond.

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    Manufacturing Associate (Molecular Techniques)

    We are seeking a Manufacturing Associate to apply hands-on training to perform the production of innovative reagents according to established SOPs and batch records, as well as troubleshoot technical challenges related to their production and downstream use. A successful candidate will have an enthusiastic entrepreneurial work ethic and will be driven to meet the Codex DNA production forecast and timelines. The candidate will work closely with the Manufacturing Team, Process Development, Research & Development, Customer Service, and Quality.

     

    Essential Duties and Responsibilities:

    • Perform basic molecular biology workflows for research use only reagent manufacturing, including products used for DNA synthesis and assembly.
    • Complete all Production tasks as scheduled, applying best practices in the development, initiation, planning, execution, control and closing of manufacturing orders.
    • Customer-driven focus and willingness to manage numerous orders at once.
    • Strictly adhere to established policies and procedures for reagent manufacturing and quality control; and report any problems with documentation.
    • Willingness to constantly innovate and reduce costs without compromising quality.
    • Supports quality investigations, root cause analysis, corrective actions, preventive actions, and quality system continuous improvement initiatives.
    • Interfaces with scientific team members in Manufacturing and Product Development to understand new methods pertaining to synthetic biology.
    • All other reasonable tasks as may be requested by the Team Leader and/or the Production Supervisor.

     

    Working Conditions:

    • This position is based in our San Diego, CA office. This role requires the ability to report to the office 5 days per week.
    • Prolonged periods of sitting at a desk and working on a computer
    • Ability to lift 15 pounds required
    Organization
    Codex DNA
    Organization Website
    Job Location

    9535 Waples St Suite 100
    San Diego, CA 92121
    United States

    Requirements

    Required Qualifications:

    • 1+ years’ experience in molecular biology techniques including cloning, PCR, gene synthesis design and assembly, mutagenesis and sequence analysis is highly desirable.
    • Ability to effectively communicate options technical results, formulate and interface with R&D, manufacturing, and technical support is required.
    • Self-motivated, hard-working, detail-oriented and able to work in a fast-paced team environment with demonstrated problem solving skills.
    • Excellent time management skills and ability to work independently.
    • Working computer literacy using an ERP system, emails, spreadsheets, and word processing software.
    • Excellent math skills, strong organizational skills, and very detail oriented.
    • Familiar with cGMP, ISO9000/13485, product specifications incoming inspection procedures.
    • Effective verbal and written communication, analytical, and interpersonal skills.
    • Performs excellent internal and external customer service.

     

    Education Requirements:

    • Requires a Bachelor’s degree in Biology or related field with 2+ years of relevant work experience in Biotech industry.
    About Our Organization

    Our mission is to apply our breakthroughs in automation solutions for DNA, RNA, and protein synthesis to enable customers to program and "write" synthetic biology that creates sustainable healthcare and technology solutions for some of humanity’s biggest challenges.  Our gene synthesis portfolio reduces the turnaround time for synthesizing workflows from weeks and months to days and hours, and includes the BioXp™ system, DNA services, Gibson Assembly® reagents, and Vmax™ chemically competent cells.  In addition to automating, accelerating, and optimizing DNA design, synthesis, cloning and amplification, Codex DNA and the BioXp™ system ensure your designs stay in your hands, marrying speed and security for innovators in drug discovery, vaccine development, precision medicine, and beyond.

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    360Dx