Bio-Rad Laboratories has launched the CFX Opus 96 Dx System and CFX Opus 384 Dx System, real-timePCR detection systems that have been listed with the US Food and Drug Administration and received CE marking for in vitro diagnostic use. The CFX Opus 96 Dx features a fixed 96-well sample block and can multiplex up to five targets per well with reaction volumes ranging from 1 to 50 uL. The CFX Opus 384 Dx features a fixed 384-well sample block and can multiplex up to four targets per well with reaction volumes ranging from 1 to 30 uL.
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Twist Bioscience has launched the Twist Exome 2.0 panel for targeted next-generation sequencing.
The hybridization-based library prep kit provides coverage of protein-coding regions from major genetic databases, including RefSeq, CCDS, GenCode, Clinvar, ACMG73, and more, as well as coverage of clinically-relevant non-coding pathogenic and likely pathogenic variants.
Single-Cell Multiomic Analysis of Thymocyte Development
CD4 and CD8 T cells play critical roles in the mammalian immune system. While their development within the thymus from the CD4+CD8+ stage has been widely studied as a model of lineage commitment, the underlying mechanism remains unclear.
In this webinar, Aaron Streets of UC Berkeley will discuss how this process can be deconstructed by applying CITE-seq to measure the transcriptome and over 100 surface proteins in thymocytes from wild-type and lineage-restricted mice. Streets will explain how totalVI can be used to jointly analyze the paired measurements to build a comprehensive timeline of RNA and protein expression in each lineage. This data supports a sequential model of lineage determination in which both lineages go through an initial phase of CD4 lineage audition, which is followed by divergence and specification of CD8 lineage cells.Participants can expect to learn:
- How the totalVI computational pipeline can be used to interpret CITE-seq data.
- How single-cell multiomic measurements can be integrated with traditional flow cytometry to generate a hypothesis.
- A comprehensive model for T-cell development in the thymus.
Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes.
A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports.
Wired reports that more US states are passing genetic privacy laws.
In Science this week: poaching has led to the rapid evolution of tuskless African elephants.
The pharma firm is lending its large sales force to help promote the test across hospitals and clinics treating patients with hematologic cancers.
Researchers are identifying stable and shifting gene expression and metabolite associations in blood samples collected from hundreds of female participants over nine years.
Lemonaid Health, based in San Francisco, offers a platform that provides online access to a variety of telemedicine and pharmacy services.
BioFlyte, a developer of airborne pathogen detection systems, has named John Bolton to its board of directors. Bolton most recently served as the US National Security Advisor from 2018 to 2019. He also served as the US Ambassador to the United Nations. Ambassador Bolton is expected to help drive awareness of BioFlyte and its bio-threat detection technology within the global security market.
Becton Dickinson has named infectious diseases specialist Carrie Byington to its board of directors. Byington is executive VP and head of University of California Health. Prior to UCH, Byington held leadership roles at the Texas A&M University System, including serving concurrently as dean of the college of medicine and senior vice president of health sciences for Texas A&M University and vice chancellor for health services for the Texas A&M 11-campus system. She also spent more than 20 years in teaching and leadership positions with the University of Utah.
DNA Script has appointed Don Kania as chairman of its board of directors, Catherine Moukheibir as audit chair, and Bonnie Anderson as independent director.
Kania is an advisor to several startups and the former CEO of FEI Company. Moukheibir was most recently the CEO and chair of MedDay Pharmaceuticals. Anderson served as CEO and board chairman of Veracyte until June of this year, when she became executive chairwoman.
A postdoctoral position is available in the laboratory of Dr. Kathleen Fisch in the UC San Diego School of Medicine Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal-Fetal Medicine, part of the newly established Center for Perinatal Discovery. The lab focuses on the application of genomics to discover biomarkers that can predict pregnancy disorders and adverse fetal outcomes in order to improve maternal-fetal health. The candidate will be supported by NIH awards and will be involved in the following research initiatives:
- Analysis of human placenta sequencing data (e.g. scRNAseq, scATACseq, spatial transcriptomics) as a member of the HuBMAP Female Reproductive Tissue Mapping Center (https://hubmapconsortium.org/).
- Design and analysis of clinical research studies involving technologies such as single cell and bulk transcriptomics, epigenomics, genomics, proteomics and metabolomics.
- Analysis of extracellular RNA and genomics data in the context of chronic pain as a member of the A2CPS Consortium (https://a2cps.org/).
This position affords ample opportunity for academic growth, multi-institutional and multi-disciplinary collaborations. The successful candidate will be encouraged to explore new research areas and seek independent funding to establish a pathway for independence. The ideal candidate will be expected to draft manuscripts and present results at professional meetings. Candidates are required to have a Ph.D. or M.D./Ph.D. in molecular and cellular biology or a related discipline with an emphasis on clinical research, reproductive science, epidemiology, or molecular biology. The ideal candidate will have a strong background in molecular biology with excellent quantitative analytical skills and familiarity with next generation sequencing technologies and lab protocols.
Applicants are expected to be within two years of completing graduate studies and have a strong publication record with excellent writing and communication skills. Experience with the R programming language is preferred. While computational skills are desirable, highly motivated candidates aspiring to acquire these skills will be considered and training will be provided.
9500 Gilman Drive
La Jolla, CA 92093
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. The Office of Research Affairs at UC San Diego is committed to academic excellence and diversity within the academic, staff, and student body. Salary is commensurate with qualifications and based on published University of California pay scales
If interested, please email a cover letter summarizing current research and career goals, curriculum vitae, and list of three references to Dr. Kathleen Fisch.
Researchers from Parse Biosciences and 10x Genomics and their collaborators discussed the ability of their platforms to process up to 1 million cells simultaneously.