Sudden cardiac death following myocardial infarction (MI) is one of the leading causes of mortality in the world, resulting in an estimated 4 million to 5 million deaths each year. Recent advances have drastically improved the acute survival of MI, yet long-term survival rates have only marginally improved over the last few years. Researchers at University Hospital Aachen in Germany aimed to address this unmet medical need for novel, long-term MI therapeutic options using the Visium Spatial Gene Expression Solution from 10x Genomics.
In this webinar, Christoph Kuppe, Jovan Tanevski, Rafael Kramann, and Julio Saez-Rodriguez, winners of the 10x Genomics Visium Spatial Scientific Challenge, will describe:
- How they generated a map of human MI at unprecedented resolution using the Visium Spatial Gene Expression Solution in both healthy human cardiac tissue and old human MI diseased tissue.
- How they performed state-of-the-art single nuclear RNA sequencing and single cell ATAC (Assay for Transposase-Accessible Chromatin) sequencing in healthy and infarcted cardiac tissue.
- The significance of combining single-cell, single-nucleus, and spatial gene expression analyses for gleaning novel insights into mechanisms and potential therapeutic targets.