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April 30, 2020
Sponsored by
10x Genomics

Whole-Transcriptome Spatial Mapping of the Healthy and Infarcted Human Heart


Sudden cardiac death following myocardial infarction (MI) is one of the leading causes of mortality in the world, resulting in an estimated 4 million to 5 million deaths each year. Recent advances have drastically improved the acute survival of MI, yet long-term survival rates have only marginally improved over the last few years. Researchers at University Hospital Aachen in Germany aimed to address this unmet medical need for novel, long-term MI therapeutic options using the Visium Spatial Gene Expression Solution from 10x Genomics.
In this webinar, Christoph Kuppe, Jovan Tanevski, Rafael Kramann, and Julio Saez-Rodriguez, winners of the 10x Genomics Visium Spatial Scientific Challenge, will describe:

  • How they generated a map of human MI at unprecedented resolution using the Visium Spatial Gene Expression Solution in both healthy human cardiac tissue and old human MI diseased tissue.
  • How they performed state-of-the-art single nuclear RNA sequencing and single cell ATAC (Assay for Transposase-Accessible Chromatin) sequencing in healthy and infarcted cardiac tissue.
  • The significance of combining single-cell, single-nucleus, and spatial gene expression analyses for gleaning novel insights into mechanisms and potential therapeutic targets.
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