Direct detection of viral RNA in human or other animal cells by RNA in situ Hybridization (ISH) is a powerful tool to establish the etiology and pathogenesis of viral disease. Nucleic acid-based molecular detection methods have revolutionized viral detection, offering several essential advantages such as sensitivity, specificity, and speed.

Beyond this, RNAscope ISH uniquely offers molecular detection coupled with morphological context to enable visualization of the virus in different infected tissues and cell types.