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August 24, 2020
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Utility of Novel RNA-Based Tools in Oncology Drug Development


This webinar, Part 1 of the “Advances in RNA-based Biomarker Development for Precision Oncology” webinar series sponsored by GeneCentric Therapeutics, will discuss how gene expression signatures can accelerate (and rehabilitate) drug programs, define targeted patient populations, expand drug indications, and improve clinical success.

Speakers will detail a range of topics, including how expression-based subtyping can eclipse DNA targeted panel technologies in determining patient’s likely response to treatment; the use of clinical subtypes and custom response signatures to select the right therapy for the right patient to improve treatment responses; and the identification of new tumor types for therapies.

Joel Parker of the University of North Carolina at Chapel Hill will discuss the identification of diverse molecular phenotypes with RNA-seq, focusing on expressed mutations, immune phenotypes, and viral detection and quantification.

Kirk Beebe of GeneCentric Therapeutics will follow with a presentation outlining the use of RNA-seq for bolstering drug development programs by circumventing mutational status and deciphering the functional expression of tumors. In particular, he will discuss how bulk tumor sequencing offers the ability to simultaneously assess diverse members of the tumor microenvironment such as cancer and immune cells and will share details of how this approach has been applied in both targeted and immunotherapies.

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The New York Times reports that the US Food and Drug Administration has authorized Johnson & Johnson's SARS-CoV-2 vaccine.

Nature News writes that additional details about the UK plan for an agency to support high-risk, high-reward science are needed.

The Wall Street Journal writes new studies are giving glimpses into the origins of SARS-CoV-2.

In PLOS this week: analysis of Plasmodium population structure, qPCR assay to diagnose scabies, and more.

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In this webinar, Felix J. Hartmann of Stanford University will describe an approach that characterizes the metabolic regulome of individual cells together with their phenotypic identity.

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10x Genomics

The human immune system is extremely complex, comprised of multiple cell types and states interacting in myriad ways to produce diverse cellular ecosystems.