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The growing use of circulating cell-free (cfDNA) necessitates accurate variant detection at less than 1% allele frequencies due to a low population of DNA of interest within total cfDNA. This level of detection is critical for a variety of cfDNA applications including detection of circulating tumor DNA (ctDNA), detection of graft-derived cfDNA (GcfDNA) within normal plasma as a marker of graft integrity after organ transplantation, and for noninvasive prenatal testing (NIPT) where fetal cfDNA is detected at low frequencies in maternal plasma. 

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Researchers uncovered the HIV virus within a tissue sample collected in 1966, the Atlantic reports.

Nature News reports there are a handful of clinical trials underway to evaluate vaginal microbiome seeding of newborns born via caesarian section.

The Washington Post writes that humans may have contributed to the extinction of cave bears some 20,000 years ago.

In PLOS this week: gene variant may protect against trypanosomiasis, GLIS3 role in type 2 diabetes, and more.

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This webinar will illustrate how single-cell methylation sequencing can be applied to gain significant insight into epigenetic heterogeneity in disease states, advancing cancer research discoveries.