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October 06, 2020
Sponsored by
10x Genomics

Understanding Human Pulmonary Fibrosis using Single-Cell Technologies


Boehringer-Ingelheim Endowed Professor of Internal Medicine,
Chief of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by irreversible scarring of the distal lung, leading to respiratory failure. Currently, there is no cure for the disease and while studies have pointed to possible distinguishing molecular features, high-resolution cellular insights are still needed.

Harnessing technologies such as single-cell RNA-sequencing (scRNA-seq) may enable a better understanding of the cellular and molecular processes that determine the IPF lung phenotype, and lead to the identification of novel, cell type-specific therapies and biomarkers. 

In this webinar, Dr. Naftali Kaminski of Yale University will describe research that leveraged scRNA-seq to uncover the diversity and complexity of aberrant cellular populations in the IPF lung.

Dr. Naftali Kaminski will discuss details of the study and its findings, including:

  • Steps to generate a comprehensive IPF lung cell atlas from 312,928 cells collected from human IPF lungs, chronic obstructive pulmonary disease lungs, and control donor lungs
  • Identification of a previously undescribed aberrant basaloid cell type highly expressing genes implicated in the pathogenesis of IPF and marked by features characteristic of cells involved in distal airway development and repair
  • Resulting hypotheses on the relationships between the transcriptional profiles of cells identified in IPF lung tissues, function, localization in tissue, and disease pathophysiology
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In this webinar, Felix J. Hartmann of Stanford University will describe an approach that characterizes the metabolic regulome of individual cells together with their phenotypic identity.

Sponsored by
10x Genomics

The human immune system is extremely complex, comprised of multiple cell types and states interacting in myriad ways to produce diverse cellular ecosystems.