Close Menu
October 06, 2020
Sponsored by
10x Genomics

Understanding Human Pulmonary Fibrosis using Single-Cell Technologies

GenomeWebinar

Boehringer-Ingelheim Endowed Professor of Internal Medicine,
Chief of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale School of Medicine

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by irreversible scarring of the distal lung, leading to respiratory failure. Currently, there is no cure for the disease and while studies have pointed to possible distinguishing molecular features, high-resolution cellular insights are still needed.

Harnessing technologies such as single-cell RNA-sequencing (scRNA-seq) may enable a better understanding of the cellular and molecular processes that determine the IPF lung phenotype, and lead to the identification of novel, cell type-specific therapies and biomarkers. 

In this webinar, Dr. Naftali Kaminski of Yale University will describe research that leveraged scRNA-seq to uncover the diversity and complexity of aberrant cellular populations in the IPF lung.

Dr. Naftali Kaminski will discuss details of the study and its findings, including:

  • Steps to generate a comprehensive IPF lung cell atlas from 312,928 cells collected from human IPF lungs, chronic obstructive pulmonary disease lungs, and control donor lungs
  • Identification of a previously undescribed aberrant basaloid cell type highly expressing genes implicated in the pathogenesis of IPF and marked by features characteristic of cells involved in distal airway development and repair
  • Resulting hypotheses on the relationships between the transcriptional profiles of cells identified in IPF lung tissues, function, localization in tissue, and disease pathophysiology
 
Sponsored by

Two COVID-19 vaccine developers have released their trial protocols to build public trust, the New York Times reports.

A new analysis finds the rapid COVID-19 test from DnaNudge to be highly accurate, Reuters reports.

In Science this week: global citizens' assembly on genome-editing technologies proposed, epigenetic markers predict metformin response, and more.

According to the Verge, many US states are not including positive results from rapid COVID-19 testing in their case numbers.

Oct
06
Sponsored by
10x Genomics

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by irreversible scarring of the distal lung, leading to respiratory failure. 

Nov
09
Sponsored by
Akoya Biosciences

Most recent single-cell and spatial biology studies have focused on the network of interactions between different cell types and their spatial context.