Close Menu
November 09, 2020
Sponsored by
Akoya Biosciences

The Tumor Neighborhood Watch: How Spatial Architecture and Cellular Neighborhoods Correlate to Colorectal Cancer Outcomes

GenomeWebinar

Rachford and Carlota A. Harris Professor,
Department of Pathology, Stanford University

Most recent single-cell and spatial biology studies have focused on the network of interactions between different cell types and their spatial context. However, studying tumor biology at two different levels — the interacting cell types as well as the tissue regions within which they are organized — can give further insight into tumor progression and immunotherapy response.

Dr. Garry Nolan and his team at Stanford University collaborated with the University of Bern to conduct deep single-cell phenotyping and spatial analysis on a cohort of colorectal cancer formalin-fixed, paraffin-embedded samples using the CODEX (CO-Detection by indEXing) platform from Akoya Biosciences. As a result, the authors discovered nine distinct cellular neighborhoods, each uniquely composed of certain immune and cancer cell types. These cellular neighborhoods were found to interact with one another in a manner that correlated with disease progression and prognosis.

In this webinar, Dr. Nolan will discuss the findings from the study and present an analytical framework to analyze high-dimensional imaging data that can reveal new insights into how the tumor microenvironment is organized.

Learning objectives:

  • How to use high-dimensional imaging to study tumor biology at the single-cell and tissue architecture levels
  • How spatial interactions between cellular aggregates in the tumor microenvironment contribute to disease progression and prognosis in colorectal cancer
Sponsored by

A survey by Nature finds that most researchers want scientific meetings to continue virtually or with a virtual component, even after the pandemic ends.

Certain blood proteins may be able to distinguish COVID-19 patients who will become critically ill from those who will not, the Atlanta Journal-Constitution reports.

Bloomberg reports that the B.1.351 SARS-CoV-2 viral variant could prompt the formulation of better vaccines.

In Genome Biology this week: algorithm to assess regulatory features, approach to integrate multiple single-cell RNA-seq datasets, and more.

Mar
11
Sponsored by
Foundation Medicine

In this session, the third in the Precision Oncology News Virtual Molecular Tumor Board Series, our expert panelists will review patient cases in which genomic profiling has identified gene fusions that may or may not serve as druggable targets.

Mar
17
Sponsored by
IONPath

In this webinar, Felix J. Hartmann of Stanford University will describe an approach that characterizes the metabolic regulome of individual cells together with their phenotypic identity.

Mar
23
Sponsored by
Roche

This webinar will discuss findings from the study, in which molecular residual disease (MRD) was assessed using circulating tumor DNA (ctDNA) without prior mutational knowledge in oligometastatic colorectal cancer (CRC) patients who had received neoadjuvant chemotherapy. This study also investigated urine as an alternative analyte for ctDNA MRD detection.

Mar
24
Sponsored by
Mission Bio

This webinar, the first in a “Women in Single Cell” series sponsored by Mission Bio, will discuss the use of single-cell analysis to assess genome editing for use in pre-clinical disease modeling.