Host immune responses play a central role in controlling SARS-CoV-2 infection, but they remain incompletely characterized and understood.
In this webinar, Dr. Yapeng Su of the Institute for Systems Biology will present an integrated analysis of the clinical measurements, immune cells, and plasma multiomics of 139 COVID-19 patients representing all levels of disease severity, from serial blood draws collected during the first week of infection following diagnosis.
As recently published in Cell, Dr. Su’s team identified a major shift between mild and moderate disease, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes. Within this stressed plasma environment at moderate disease, multiple unusual immune cell phenotypes emerge and amplify with increasing disease severity.
Dr. Su and colleagues condensed more than 120,000 immune features into a single axis to capture how different immune cell classes coordinate in response to SARS-CoV-2. This immune-response axis independently aligns with the major plasma composition changes, with clinical metrics of blood clotting, and with the sharp transition between mild and moderate disease.
This study suggests that moderate disease may provide the most effective setting for therapeutic intervention.