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February 18, 2021
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Single-Cell Multiomics to Elucidate Immune Alterations in the Human Tumor Microenvironment


Associate Professor,
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center

The composition of the immune infiltrate in the human tumor microenvironment is a critical determinant of disease progression. However, it has been unclear how tumor-specific inflammatory processes relate to inflammation in non-malignant tissues.

This webinar will discuss a single-cell study that compared the immune landscape of human head and neck squamous cell carcinoma (HNSCC) in the oral and oropharyngeal cavity to inflamed oral mucosal tissue samples, in an effort to identify tumor-unique immune alterations.

Dr. Martin Prlic of the Fred Hutchinson Cancer Research Center will share details of the project, which found a considerable phenotypic congruence of immune cells in inflamed versus tumor tissues, including the presence of T cells with an exhausted phenotype as well as recently described mature dendritic cells enriched in immunoregulatory molecules (mregDCs).

Computational and machine learning analyses revealed previously unidentified tumor-unique immune subsets and signaling axes, while experimental validation confirmed a tumor-unique subset of regulatory T cells (Tregs).

Attendees of this webinar will learn:

  • How cutting-edge single-cell techniques are used to study the microenvironment in human tissue samples
  • Insights into the immune alterations in the human tumor microenvironment
  • A blueprint for a novel discovery approach of immunotherapeutic targets in the human tumor microenvironment
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