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March 24, 2021
Sponsored by
Mission Bio

Single-Cell Analysis and Genome Editing in Preclinical Disease Modeling: Detailed Insights into Leukemia Lineage

GenomeWebinar

Staff Scientist in the Department of Pathology,
St. Jude Children’s Research Hospital, Memphis

This webinar, the first in a “Women in Single Cell” series sponsored by Mission Bio, will discuss the use of single-cell analysis to assess genome editing for use in pre-clinical disease modeling.

Our invited speaker, Ilaria Iacobucci of St. Jude Children’s Research Hospital, will discuss the benefits of using single-cell analysis to quantify and characterize genome editing experiments.

In particular, she will discuss a study she co-authored that was published in Blood, “Modeling and targeting of erythroleukemia by hematopoietic genome editing,” in which she developed faithful experimental models of  acute erythroid leukemia (AEL) in mice by multiplex genome editing of recurrently co-mutated genes.

As part of this work, Dr. Iacobucci and colleagues used single-cell analysis determine mutational co-occurrence and sequence of acquisition of multiple tumor stages, identifying primary and secondary mutations that promote clonal fitness and genesis of the leukemic phenotype.

Dr. Iacobucci’s presentation will be followed by a live audience Q&A that will discuss this work as well as her experience as a pioneering woman in single-cell research.

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