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Commutability is critical for a reference material for use in analytical validation for highly sensitive circulating tumor DNA (ctDNA) assays using next generation sequencing (NGS). ctDNA analogues that rely on traditional shearing methods via focused sonication alone result in material that amplifies poorly in library preparation. Low library preparation yields are mostly likely due to a broad range of DNA fragments and damaged DNA ends, which prevent proper library formation.

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A UK woman is suing three National Health Service Trusts for not telling her about her father's Huntington's disease diagnosis, the BBC reports.

LiveScience reports that a novel mutation in the LPL gene was uncovered in three siblings with very high triglyceride levels.

The president of Nankai University is embroiled in a data manipulation scandal, the South China Morning Post reports.

In PNAS this week: cytotoxic CD4 T cell signature in supercentenarians, evolutionary history of beetles, and more.