This webinar highlights the use of single-cell genomics to identify distinct cell types and states associated with enhanced immunity.
Immune homeostasis requires constant regulation in order to maintain the balance between a diverse and dynamic set of cell types under normal physiological conditions. Within immune tissues, distinct cellular subsets must work together to defend against pathogenic threats, maintain tolerance, and establish memory to restore homeostasis. While surveying multiple healthy individuals enables the exploration of potential ensemble immune solutions, comparing this data against outliers of health and disease can reveal deviations that underscore diagnostic, therapeutic, and prophylactic features of enhanced function or dysfunction.
In this webinar, Alex K. Shalek of the Massachusetts Institute of Technology (MIT) discusses his work using single-cell genomic approaches — in particular, single-cell RNA-seq — to explore the functional diversity among immune cells within and across individuals. This project aims to uncover distinct cell types and states associated with improved immunity from the molecular level.
Dr. Shalek also expands on the emerging experimental and computational strategies for altering ensemble cellular responses through targeted intra- or extracellular induction of preferred cell types and states.