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October 08, 2019
Sponsored by
10x Genomics

Integration of Single Cell and Spatially Resolved Methods for Understanding Neurodegeneration in ALS

GenomeWebinar

This webinar discusses a study that used spatial transcriptomics to gain insight into the molecular mechanisms of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease.

Mounting evidence indicates that dysfunction in signaling between motor neurons and glia is a key component of ALS, but limitations of traditional gene expression profiling technologies, such as low throughput or lack of spatial resolution, have so far stymied efforts to understand how this dysfunction participates in the onset and spread of ALS pathology in the spinal cord.

Our speaker, Silas Maniatis of the New York Genome Center, shares how his team sought to gain a spatially resolved view of disease-driven gene expression changes that order these events.

Dr. Maniatis discusses how the NYGC team and collaborators from the Flatiron Institute, SciLifeLab, and the Broad used spatial transcriptomics — which generates quantitative transcriptome-wide RNA sequencing data through the capture of polyadenylated RNA on arrays of spatially barcoded DNA capture probes — to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients.

The study resulted in a comprehensive spatiotemporal, transcriptome-wide gene expression dataset combining resolution, replication, and biological perturbation. Dr. Maniatis discusses data from the study as well as the broader potential of the work for future studies of central nervous system disorders.

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A study of families explores how children transmit SARS-CoV-2, according to the Associated Press.

US Agricultural Research Service scientists have sequenced the genome of the Asian giant hornet.

According to the Economist, pooled testing for COVID-19 could help alleviate strains on testing labs.

In Science this week: MIT researchers outline approach dubbed translatable components regression to predict treatment response among IBD patients.

Aug
13
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10x Genomics

This webinar will discuss a study that combined single-cell gene expression and spatial gene expression to understand the evolution of sepsis in the kidney at the cellular and molecular level.

Aug
18
Sponsored by
Bio-Rad

As worldwide COVID-19 cases continue to rise, there is a significant need to increase testing and population surveillance capacity.

Aug
24
Sponsored by
Genecentric

This webinar, Part 1 of the “Advances in RNA-based Biomarker Development for Precision Oncology” webinar series sponsored by GeneCentric Therapeutics, will discuss how gene expression signatures can accelerate (and rehabilitate) drug programs, define targeted patient populations, expand drug indications, and improve clinical success.

Aug
26
Sponsored by
Bionano Genomics

Alzheimer’s disease is genetically complex with no meaningful therapies or pre-symptomatic disease diagnostics.