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October 01, 2020
Sponsored by
Adaptive Biotechnologies

Immune Repertoire Sequencing to Uncover SARS-CoV-2-Specific T Cell Responses and Dynamics


Chief of the Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases at the National Institutes of Health

Bioinformatician, NIAID Collaborative Bioinformatics Resource (NCBR)/Leidos

VP Research for immunoSEQ Dx, Adaptive Biotechnologies

T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of antibodies by B cells. This central role for T cells makes them a desirable target for assessing the immune response to SARS-CoV-2 infection. 

In this webinar we’ll discuss:

  • Information and early insights from Adaptive Biotechnologies’ open-access ImmuneCODE COVID-19 database
  • Demonstrate how high-throughput sequencing of the T-cell receptor beta repertoire may reveal SARS-CoV-2-specific clonotypes
  • Describe the epidemiology of COVID-19 in a cohort of patient samples from Northern Italy
  • Discuss the presence of public SARS-CoV-2-specific clonotypes in COVID-19 patient samples and controls
  • Analyze differences in the clonal distribution of SARS-CoV-2-specific T cell clonotypes according to different degrees of disease severity
  • Reveal changes in frequency (expansions vs. contractions) of SARS-CoV-2 clonotypes during evolution of the disease

For Research Use Only. Not for use in Diagnostic Procedures.

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