May 23, 2017
Sponsored by
Agilent Technologies

High-Confidence Mutation Detection in Chronic Lymphocytic Leukemia Gene Targets

GenomeWebinar

Assistant Professor, Director, Clinical NGS Assay Development, Molecular Diagnostic Laboratory, Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center

This webinar will discuss a target enrichment workflow for high-confidence detection of variants. Our speaker, Rajesh Singh of MD Anderson Cancer Center, will detail a project that used this workflow for variant detection in chronic lymphocytic leukemia gene targets.

Target capture and enrichment of genomic regions of interest is a crucial but challenging step for successful targeted next generation sequencing. Challenges include compatibility with DNA quality and input, uniform and efficient capture of the targeted genomic regions, and high-confidence detection of a variety of variants.

The HaloPlexHS target enrichment workflow uses circularization probes for rapid capture and enrichment of genomic areas of interest with high specificity for NGS library preparation. The use of endonuclease digestion of the template and molecular barcodes provide overlapping amplicons for enhanced sequencing coverage and high-confidence detection of variants.

In this webinar, Dr. Singh will discuss how his team applied the HaloPlexHS workflow to variant detection in CLL gene targets. 

For Research Use Only. Not for use in diagnostic procedures.
Sponsored by

Two researchers have found that behavioral genetic defenses in criminal cases don't tend to affect outcomes, according to Popular Science.

Researchers report that while host genetics influence the oral microbiome, they don't appear to affect cavity-causing microbes, the Economist says.

Pandas' gut microbiomes change as what they eat changes with the seasons, writes Discover's Inkfish blog.

In PLOS this week: comparative genomic study of malaria-linked macaque parasite, search for apple root reference genes, and more.

Sep
27
Sponsored by
Philips Genomics

This webinar will present an in-depth look at how Memorial Sloan Kettering Cancer Center has developed and implemented a next-generation sequencing panel for mutational tumor profiling of advanced cancer patients.

Oct
12
Sponsored by
PierianDx

This webinar will be a roundtable discussion on the adoption of a commercial gene panel for tumor profiling at several leading US cancer centers. 

Oct
17
Sponsored by
Cofactor Genomics

This webinar will discuss the benefits of genomically profiling the immune microenvironment of soft tissue sarcomas during neoadjuvant therapy.