April 11, 2017
Sponsored by
Personal Genome Diagnostics

Genomic Predictors of Immunotherapy Response


Director of Ambulatory Treatment Center and Emergency Care, Director of Hematology/Oncology for The University of Texas, Houston Internal Medicine Residency Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center

Oncology Science Liaison, PGDx

This webinar provides an overview of genomic alterations that play a role in immunotherapy response.

Impressive response rates to checkpoint inhibitors have been observed in subsets of tumors with high tumor mutational burden due to mutations in DNA polymerase epsilon (POLE) and mismatch repair genes (MMR) across histologies. Mutations in the MMR pathway lead to microsatellite instability (MSI), which is characterized by alterations in the length of repeated DNA microsatellite sequences. The MSI phenotype was originally described for inherited tumors associated with Lynch syndrome and was later identified in sporadic tumors. The prevalence of MSI is higher in colorectal, endometrial, and gastric cancers, but MSI has been observed in many tumor types at varying frequencies.

In this webinar, Dr. Michael Overman of the University of Texas MD Anderson Cancer Center discusses the molecular mechanisms of immunotherapy response. In particular, he provides evidence that MSI-high and other hyper-mutated tumors have large numbers of neoantigens to which the immune system can respond when primed by checkpoint blockade. 

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This online seminar will provide an overview of the use of liquid biopsies for cancer recurrence monitoring with a particular focus on colorectal cancer.

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This webinar will provide an overview of an RNA-seq protocol that has been optimized to study small RNA species such as microRNAs.

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Agilent Technologies

This webinar will discuss a target enrichment workflow for high-confidence detection of variants. 

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This webinar will discuss RNA sequencing as an alternative to immunohistochemistry (IHC) in selecting patients for cancer immunotherapy.