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Next-generation sequencing (NGS) of liquid biopsies offers a minimally invasive alternative to solid tissue biopsies and a more holistic profile of intra- and inter-tumoral heterogeneity for therapy
selection and disease monitoring. However, NGS analysis of circulating tumor DNA (ctDNA) is highly
centralized owing to cumbersome workflows, complex assays, and a lack of high-performance kitted
solutions. We present a sensitive, scalable, and efficient targeted amplicon sequencing workflow and

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.