July 20, 2017
Sponsored by
NuGEN

Characterization of Gene Fusions in Distinct Subtypes of Melanoma

GenomeWebinar

Research Instructor, Cutaneous Oncology Program,
Division of Medical Oncology, Department of Medicine,
University of Colorado Anschutz Medical Campus

Director, Technical Support, NuGen

This webinar describes the characterization of gene fusions across distinct subtypes of melanoma.

The majority of common sun exposure-related melanomas have high mutational burden and activating mutations in the BRAF kinase gene. In contrast, less common subtypes of melanoma not related to sun exposure (acral lentiginous and mucosal melanomas) have low mutation burden, generally lack BRAF mutations, and have increased frequency of genomic structural variants. Activating gene fusions in BRAF have been reported in melanomas lacking mutations in BRAF and other common melanoma driver genes, but gene fusions and their therapeutic potential have not been well studied across different subtypes of melanoma.

To characterize gene fusions, Kasey Couts and colleagues at the University of Colorado Anschutz Medical Campus performed targeted RNA sequencing of 65 melanoma patient-derived xenograft (PDX) models representing different melanoma subtypes (sun-exposed and non-sun-exposed) and genotypes (with or without common driver mutations). They identified several kinase gene fusions in melanomas lacking other driver mutations and tested the therapeutic potential in pre-clinical models using specific small molecule inhibitors.

During this webinar, Dr. Couts describes the gene fusion targeted RNA sequencing screen and discuss the results, which include identification of an ALK fusion (EML4-ALK) occurring in a malignant melanoma. She also discusses the successful response to targeted inhibitors in melanomas with various kinase fusions. This webinar highlights the clinically significant finding of targetable gene fusions in both sun-exposed and non-sun-exposed subtypes of melanoma.

Sponsored by

Researchers report that while host genetics influence the oral microbiome, they don't appear to affect cavity-causing microbes, the Economist says.

Two researchers have found that behavioral genetic defenses in criminal cases don't tend to affect outcomes, according to Popular Science.

Pandas' gut microbiomes change as what they eat changes with the seasons, writes Discover's Inkfish blog.

In PLOS this week: comparative genomic study of malaria-linked macaque parasite, search for apple root reference genes, and more.

Sep
27
Sponsored by
Philips Genomics

This webinar will present an in-depth look at how Memorial Sloan Kettering Cancer Center has developed and implemented a next-generation sequencing panel for mutational tumor profiling of advanced cancer patients.

Sep
28
Sponsored by
Fabric Genomics

This webinar will discuss the critical role that software can play for clinical labs looking to establish comprehensive genomic testing programs. 

Oct
12
Sponsored by
PierianDx

This webinar will be a roundtable discussion on the adoption of a commercial gene panel for tumor profiling at several leading US cancer centers. 

Oct
24
Sponsored by
OmniSeq

This webinar will discuss the advantages of a multiple-biomarker-based approach for immune profiling that provides clinicians with a rational means to consider approved immunotherapies or assign patients to immunotherapy clinical trials.