The Scan
Drug Response Variants May Be Distinct in Somatic, Germline Samples
Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.
Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis
Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.
Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff
A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.
Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications
Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.
Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis
Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.
Multiple Myeloma Progression Influenced by Immune Microenvironment Expression
Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.
Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says
A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.
Genome-Wide Analysis Sheds Light on Genetics of ADHD
A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.
MicroRNA Cotargeting Linked to Lupus
A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.
Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures
In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.