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Randy Scott, Sean George

Invitae President and Chief Operating Officer Sean George will take over as CEO, effective immediately, the company announced. Current CEO Randy Scott will continue full time at Invitae serving as executive chairman of the board of directors. The changes come as the company is focused on driving global growth in genetic testing. Previously, George was a co-founder and CEO of genetic analysis startup Locus Development. Scott previously served as executive chairman at Genomic Health and chief operating officer at personal genomics firm Navigenics.

The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.