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Personalis: Leslie Grab, John Lyle

Personalis has appointed Leslie Grab as VP of intellectual property and John Lyle as VP of assay research and development.

Grab joins the firm from Verily Life Sciences where she was responsible for worldwide patent and trademark strategy and portfolio development across multiple product areas. Prior to that, she worked at the law firm of Kilpatrick Townsend & Stockton. Grab holds a PhD in biochemistry and molecular biology from Wake Forest University and a BA in chemistry from Catawba College, North Carolina. She earned her law degree from the University of North Carolina, Chapel Hill, where she also served as a post-doctoral associate researching the inter-relationship between exosomes and ovarian cancer.

Lyle joins Personalis after 14 years at Pacific Biosciences where he most recently served as senior director of single-molecule sequencing, focusing on reagent, system, and application development of long-read, ultra-high accuracy sequencing. He received his PhD from Stanford University in microbiology and immunology and holds a BS from Bates College. Lyle also served as a post-doctoral fellow at the University of California, San Francisco, studying the structure and function of the centrosome.

The Scan

Foxtail Millet Pangenome, Graph-Based Reference Genome

Researchers in Nature Genetics described their generation of a foxtail millet pangenome, which they say can help in crop trait improvement.

Protein Length Distribution Consistent Across Species

An analysis in Genome Biology compares the lengths of proteins across more than 2,300 species, finding similar length distributions.

Novel Genetic Loci Linked to Insulin Resistance in New Study

A team reports in Nature Genetics that it used glucose challenge test data to home in on candidate genes involved in GLUT4 expression or trafficking.

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.