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John Quackenbush

Veteran computational biologist John Quackenbush has promoted to chair of the Department of Biostatistics at the Harvard T.H. Chan School of Public Health. Quackenbush, long a researcher in computational biology and bioinformatics at Dana-Farber Cancer Center and Harvard Medical School, founded the HSPH master's program in computational biology and quantitative genetics. He has been on the Harvard faculty since 2005. Quackenbush replaced Xihong Lin, who is shifting her focus to the Genome Sequencing Program of the National Human Genome Research Institute and the Trans-Omics Precision Medicine Program of the National Heart, Lung, and Blood Institute, according to a Harvard announcement.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.