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Howard Jacob

Howard Jacob has joined AbbVie as vice president of the genomic research center, leaving the HudsonAlpha Institute of Biotechnology. He had served as vice president of medical genomics and chief medical officer there since 2015. Jacob also cofounded Envision Genomics, a spinout of HudsonAlpha that aimed to make whole-genome sequencing standard of care for rare disease diagnostics. Prior to joining HudsonAlpha, Jacob served for nearly 20 years at the Medical College of Wisconsin, including as founding director of the Human and Molecular Genetics Center and as a professor of physiology. Previous to that, he was on the faculty at Massachusetts General Hospital and Harvard Medical School.

The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.