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Charles David Allis, Michael Grunstein

Charles David Allis and Michael Grunstein have been awarded the 2018 Albert Lasker Basic Medical Research award for their discoveries showing how gene expression is influenced by the chemical modification of histones. Allis is the Joy and Jack Fishman Professor at Rockefeller University, where he heads the Laboratory of Chromatin Biology and Epigenetics. Grunstein is professor emeritus in the Department of Biological Chemistry at the David Geffen School of Medicine at the University of California, Los Angeles.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.