New Products

Sep 05, 2017

Biocept NRAS Liquid Biopsy Test

Biocept has launched a new Target Selector liqud biopsy assay for mutations in the NRAS oncogene. According to the company, the NRAS mutations targeted by the test are associated with multiple cancer types such as metastatic melanoma, colorectal and lung cancer. The new test, like Biocept's other clinical assays, is run in its CLIA-certified San Diego lab. The new product brings the company's total number of Target Selector tests to 15.

Sep 01, 2017

Thermo Fisher Immune Repertoire, Liquid Biopsy NGS Assays

Thermo Fisher has launched the Ion AmpliSeq Immune Repertoire Assay Plus, TCR Beta, a research-use-only, multi-target sequencing panel for immuno-oncology applications. The new panel can be run from sample to analysis in as little as 48 hours, with up to 400-bp read-length amplicons for complete characterization of CDR1, CDR2, and CDR3, according to the company's website.

The company also launched the Ion Torrent Oncomine Lung Cell-Free Total Nucleic Acid Research Asssay, which includes fusion markers associated with lung cancer, including ALK, RET, and ROS1, in addition to DNA, RNA hotspots, copy number variants and MET exon 14 skipping. Thermo Fisher also updated the Ion Torrent Oncomine Breast cfDNA Research Assay. Version 2 now includes new CNVs, more complete coverage of key tumor suppressor gene TP53 and additional SNVs and indels. From a single tube of blood, researchers can use the assays to detect primary tumor drivers and mutations known to cause therapeutic resistance down to 0.1 percent limit of detection, the company said.

Thermo Fisher announced the new products in conjunction with the announcement that it has formed an Immuno-Oncology Consortium to drive adoption of next-generation sequencing (NGS) clinical research panels for the identification of predictive and prognostic biomarkers associated with cancer immunotherapy.

Aug 29, 2017

Dolomite Bio Single Nucleus RNA-seq Chip

Dolomite Bio plans to launch this fall a chip for the single-nucleus RNA sequencing technique, DroNc-seq, developed by researchers at the Broad Institute. The new chip is based on the company's established single-cell RNA-seq chip and is designed to produce smaller droplets to enable profiling of thousands of nuclei. The chip is compatible with Dolomite Bio's Single Cell RNA-seq System and has been optimized for single nuclei. 

Aug 24, 2017

Cynvenio Biosystems ClearID HER2 Expression Test

Cynvenio Biosystems launched its ClearID HER2 Expression Test. The liquid biopsy test allows doctors to perform real-time monitoring and analysis of HER2 levels in patients with a normal blood draw. It leverages Cynvenio's liquid biopsy technology and uses antibodies against EpCAM, TROP2, HER2, and EGFR. The test has a turnaround time of three to seven days and is processed by Cynvenio's CLIA/CAP laboratory in California.

Aug 22, 2017

Sunquest Mitogen LIMS and Genetic Analysis Software

Sunquest Information Systems has released Sunquest Mitogen, a new laboratory information management system and genetic analysis software platform to support molecular diagnostics and precision medicine. Mitogen, based in part on technology Sunquest acquired when it bought GeneInsight and UniConnect in 2016, is meant to help both wet and dry labs move into next-generation sequencing. 

Aug 21, 2017

Natera Signatera

Natera has launched Signatera, a research-use-only circulating tumor DNA assay. Signatera consists of analyzing whole-exome sequencing data from a patient's tumor sample to design a targeted, custom-designed assay to analyze 16 or more mutations that were identified in the tumor sample. According to Natera, the assay can detect variant allele frequencies down to 0.01 percent and is optimized to achieve high specificity by requiring detection of multiple mutations for a ctDNA-positive call, leading to fewer false positives.

Aug 11, 2017

Cynvenio Biosystems PD-L1 Expression Assay

Cynvenio Biosystems has launched its second-generation PD-L1 expression test. The blood test has improved analytic performance compared to the first-generation test, enabling highly sensitive and specific profiling and monitoring of PD-L1 expression on lung cancer cells recovered from blood. Cynvenio is offering the test from its CLIA/CAP laboratory in California with a three- to seven-day turnaround time. The test is also available to all Cynvenio customers running its LiquidBiopsy platform and workflow, the company said.

Aug 11, 2017

SeraCare Zika Virus Reference Materials

SeraCare Life Sciences has launched a set of reference materials for validating and monitoring Zika virus test methods. The AccuSet Zika Performance Panel is a 10-member panel consisting of patient samples demonstrating a range of reactivity for Zika IGM antibodies, and assessed for cross-reactivity to dengue and chikungunya. The panel is intended for use by researchers, diagnostic manufacturers, and clinical laboratories to develop, evaluate, and validate Zika serological test methods. The panel members have been comprehensively tested following the recommended US Centers for Disease Control and Prevention algorithm and using several commercially available methods.

SeraCare also launched the AccuSpan Zika RNA Linearity Panel and the AccuPlex Zika RNA Reference Material, both formulated using the company's AccuPlex recombinant virus technology. These safe, non-replicative, non-infectious, and fully extractable positive reference materials support the development and evaluation of molecular diagnostics detecting Zika virus.

Aug 10, 2017

Color Familial Hypercholesterolemia Test

Color launched a genetic test for familial hypercholesterolemia, a hereditary condition that causes high cholesterol, and if untreated, can lead to coronary heart disease. One in 50 people with high cholesterol are born with FH, and are 22 times more likely to develop coronary heart disease than those without FH and normal cholesterol. The physician-ordered test, priced at $249, analyzes three genes known to commonly cause FH: APOB, LDLR, and PCSK9. If customers want to get the FH test with Color's hereditary cancer risk test, the price is $349.

Aug 09, 2017

Exosome Diagnostics MedOncAlyzer 170

Exosome Diagnostics launched the MedOncAlyzer 170, a liquid biopsy pan-cancer panel that interrogates exosomal RNA and circulating tumor DNA in one assay. MedOncalyzer 170 is a targeted panel for tumor profiling that identifies clinically actionable and functionally important mutations across multiple cancer types, using as little as 0.5 ml of patient blood or plasma. 

Aug 09, 2017

Lexogen Small RNA-seq Library Prep Kit

Lexogen has launched a small RNA-seq library prep kit that is compatible with Illumina's sequencing instruments. Customers can work directly from total RNA or enriched small RNA from a variety of sources, including liquid biopsies, sorted cells, and tissues. In addition, inputs can range from 50 picograms to 1,000 nanograms of RNA. The workflow takes five hours with one hour of hands-on time. The kit comes with up to 96 unique barcodes. 

Aug 08, 2017

Canon BioMedical Novallele HRM Analyzer

Canon BioMedical has launched the Novallele HRM Analyzer, web-based software capable of analyzing data from different thermocyclers and well plate formats. The software provides an intuitive and easy-to-use graphical interface with comprehensive algorithms capable of analyzing high-resolution melting (HRM) data from different thermocyclers, Canon said. The software also complements Canon's Novallele genotyping assays, in conjunction with the Novallele Controls Sets, to analyze HRM data.

Aug 07, 2017

Geneformics D Distributed Cloud Compression Technology

Geneformics Data Systems today introduced Geneformics D, a distributed cloud compression system that promises to boost the speed of genomics data uploads, downloads, storage, and archiving by tenfold and reduce costs by 90 percent. Geneformics D is currently integrated into Amazon Web Services infrastructure, and Geneformics said it is working on versions for other cloud platforms. 

Aug 03, 2017

DNAStack Genomics Software Update

DNAStack has released an update to its genomics software platform. The cloud-based system features a new application called Workflows to assist researchers and clinicians in building, running, and sharinge bioinformatics workflows across sites. The software remains free for research; DNAStack charges per use for computation and data storage.

Aug 03, 2017

Swift Biosciences Accel-NGS 2S Indexed Adaptors

Swift Biosciences has launched Accel-NGS 2S Indexed Adaptors, a set of 96 single indices that work in combination with Illumina TruSeq adaptors to provide up to 768 unique dual-index combinations. The kit will enable users to prepare up to 96 single-indexed samples and up to 768 dual-indexed samples per run. According to the company, the kit should help prevent misassignment and index hopping as well as enable detection of low-frequency variants.

Aug 02, 2017

Bioline JetSeq Clean Kit

Bioline, a subsidiary of Meridian Bioscience, has launched the JetSeq Clean Kit, a clean-up system for next-generation sequencing workflows. The kit uses paramagnetic bead technology to purify nucleic acid fragments during NGS library prep. It removes salts, primers, primer-dimers, and dNTPs while selectively binding library fragments to magnetic particles based on their size.

Aug 02, 2017

ArcherDx VariantPlex Core Myeloid Panel

ArcherDx has launched the Archer VariantPlex Core Myeloid panel, a next-generation sequencing-based targeted panel that analyzes 37 genes related to myeloid malignancies. The company said the panel uses molecular barcoded reads, and can detect FLT3 internal tandem duplications, variants that are present in more than 20 percent of acute myeloid leukemia cases and are challenging to detect in NGS data. VariantPlex assays are provided in eight-strip, single-use lyophilized library preparation reagents that require no master mixes.

ArcherDx said that it also plans to launch a VariantPlex Myeloid panel, which expands the number of genes to 72.

Aug 02, 2017

Asuragen Expanded QuantideX qPCR BCR-ABL Portfolio

Asuragen has launched a new CE-marked QuantideX qPCR BCR-ABL minor kit for identifying minor (e1a2) BCR-ABL fusion transcripts in patients with chronic myeloid leukemia. The new test joins the firm's existing FDA-cleared and CE-marked QuantideX qPCR BCR-ABL IS Kit that covers major (e13a2, e14a2) fusions.

The two kits can be combined in a streamlined and common workflow, and Asuragen said it is also expanding the capabilities of its QuantideX Reporter, analysis software, which accompanies the CE-marked QuantideX qPCR BCR-ABL IS Kit, to allow laboratories the ability to report CML patient disease burden on the International Scale after reviewing ABL1 copy number, in compliance with European LeukemiaNet guidelines.

Aug 02, 2017

Integrated DNA Technologies Alt-R S.p. HiFi Cas9 Nuclease 3NLS Enzyme

Integrated DNA Technologies has launched the Alt-R S.p. HiFi Cas9 Nuclease 3NLS enzyme, a Cas9 enzyme variant that extensively reduces off-target effects in CRISPR genome editing without compromising on-target activity. This enzyme is a recombinant S. pyogenes Cas9 mutant that improves specificity while maintaining a high editing efficiency similar to wild-type Cas9, the company said. 

Aug 02, 2017

Genohm SLIMS Software V6.0

Switzerland-based bioinformatics firm Genohm has released version 6.0 of SLIMS, a combination laboratory information system and electronic laboratory notebook platform. The update features improved inventory tracking, the ability to send emails directly from the system, simplified workflow protocols, as well as a cleaner user interface. 

Jul 28, 2017

Synthego Modified Synthetic sgRNA Libraries for Arrayed Whole Genome CRISPR Screening

Synthego announced the availability of modified synthetic single guide RNA (sgRNA) libraries for arrayed whole human genome CRISPR screening. The arrayed libraries are delivered ready-to-screen and have comprehensive coverage of the human genome, with several guide RNAs selected per gene, using the latest algorithms to enhance knockout efficiency. This leads to superior screening capabilities over RNAi and CRISPR pooled libraries, enabling a better understanding of gene function and smarter identification of drug targets for complex diseases, the company said. The Synthego whole human genome library is available in gene families including the druggable genome, transcription factors, G-protein coupled receptors, kinases, and immunology and immuno-oncology targets, among others. This feature enables focused CRISPR screens, allowing hypothesis-driven gene targeting and running of simultaneous screens without overlap.

For a full list of the gene families visit: www.synthego.com/libraries

Jul 28, 2017

Roche Avenio Millisect System

Roche announced the commercial availability of the Avenio Millisect System, a tissue dissection instrument that utilizes an automated digitally assisted process to isolate clinically relevant cells from formalin-fixed paraffin-embedded tissue slides. The system is designed to address tissue dissection challenges in clinical labs where manual dissection lacks consistency and precision, and laser capture microscopy is cumbersome and costly, Roche said. Optimized to fit easily into a variety of clinical workflow configurations, the system allows precise and consistent recovery of regions of interest for molecular pathology, improving the results of diagnostic testing by reducing false negatives and allowing identification of additional potential therapeutic targets. The Avenio Millisect System is an IVD labeled medical device and is now available in the US and countries accepting the CE mark.

Jul 28, 2017

Agilent Technologies AriaDx Real-Time PCR System

Agilent Technologies has launched the AriaDx Real-Time PCR System in territories recognizing the CE mark for in vitro diagnostics. The modular design of customer-changeable optics in the instrument enables laboratories to use AriaDx with just one optical cartridge, and add more (up to six total) as required. The touchscreen and accompanying analysis software incorporates customer-favored features from the Stratagene Mx series while further increasing and streamlining analysis capabilities, Agilent said. The platform can be used for assays detecting gene expression, allele discrimination, and genotyping, and it is compatible with existing fast chemistry-based assays that are DNA-binding and probe-based. 

Jul 24, 2017

Helix Genomics Marketplace

Personal genomics company Helix announced the opening of an online marketplace where customers can have their DNA sequence interpreted in a variety of contexts, including health, fitness, nutrition, recreation, family, and ancestry. The marketplace features mobile applications developed by partner companies: Admera, Azumio, DNAFit, DotOne, EverlyWell, Exploragen, Genome Medical, Insitome, Intelliseq, Lose It!, National Geographic, Sema4, Titanovo, and Vinome.

The initial exome sequencing through Helix is $80, in addition to the cost for each app. For example, Sema4's CarrierCheck app enabling screening for 67 conditions is available for $199. Instiome's app, for $29.99, allows customers to learn traits they may have inherited from Neanderthal ancestors, such as skin pigmentation, the ability to repair sun damage, learning capabilities, and torso shape. 

Additionally, customers can order an app from Admera for cardiac risk, inherited cholesterol and diabetes testing; learn about their genetic ancestry from National Geographic's app; learn about how their DNA might impact sleep patterns from Exploragen; order a variety of apps for weight management and fitness based on DNA information; and receive a DNA-based taste profile from Vinome. Nursing mothers can learn their levels of the Omega 3 fatty acid in breast milk via an app from EverlyWell. An app from DotOne will let individuals order a scarf with their own DNA information printed on it.

Before or after receiving any particular interpretation, customers can also get genetic counseling through Genome Medical's telemedicine network of genetic counselors.

Jul 21, 2017

CloudLIMS Lite

CloudLIMS has released a new version of its pay-as-you-go LIMS, CloudLIMS Lite, to help biobanks and clinical, research, and testing laboratories keep track of their biospecimens and testing workflows. The new version is more efficient in facilitating testing and reporting of multiple analytes, the company said. The software can create analyte groups for each test and configure one or more analytes under a group; specify range for every analyte and create flagging sets such as high, low, critical high, critical low, et cetera, to flag test results based on obtained values; and publish test reports containing multiple analytes, among other functionalities.

Pages

Magdalena Skipper, the incoming editor-in-chief of Nature, speaks with NPR's Weekend Edition Sunday.

Genetic genealogy has led to an arrest in another cold case, dating back to 1987.

In PLOS this week: mutation in second gene widens clinical symptoms of people with ADD3 mutations, comparative genomic analysis of Pseudovibrio, and more.

Wired reports that 23andMe is trying to bolster its outside collaborations.