New Products

Jul 19, 2017

LabCorp ADAMTS13 Test

Laboratory Corporation of America began offering the ADAMTS13 test for a rare life-threatening blood-clotting disorder. The test distinguishes diseases characterized by acute thrombotic microangiopathy (TMA), a relatively rare syndrome in which small blood vessels develop blood clots. The test can provide faster and more accurate results, compared to other tests, to rule in or out the diagnosis of thrombotic thrombocytopenia purpura, a condition that can cuase TMA, and to support decisions whether to start patients on certain therapies, LabCorp said. The test is run on liquid chromatography-tandem mass spectrometry technology.

Jul 19, 2017

Quest Diagnostics QHerit Screening Service

Quest Diagnostic launched QHerit, a genetic screening service that tells individuals their risk of passing on heritable disorders to future generations. The QHerit Pan-Ethnic Expanded Carrier Screen provides information for 22 heritable diseases cited under new screening guidelines issued earlier this year by the American College of Gynecology. In addition to more well-known heritable disorders such as cystic fibrosis and sickle cell disease, QHerit also identifies lesser-known mutations associated with Joubert Syndrome 2 and fragile X syndrome. It also screens for spinal muscular atrophy and includes the evaluation of hemoglobinopathies.

Jul 18, 2017

Agilent Technologies SureSelectXT HS NGS Library Prep

Agilent Technologies has launched the Agilent SureSelectXT HS, its newest next-generation sequencing library prep product. SureSelectXT HS provides total workflow management for laboratories, from QC to target enrichment, analysis, and interpretation, the company said. It's optimized for labs with a requirement to sequence DNA from formalin-fixed paraffin-embedded samples, which may have degraded over time. SureSelectXT HS also incorporates molecular barcodes, improving overall precision and producing high complexity libraries on a broad range of tissue types and low- and high-quality FFPE samples. SureSelectXT HS libraries require as little as 10 ng of starting DNA, and use molecular barcodes to assist error correction. Additionally, faster and more efficient processing with master-mixed reagents that require less hands-on time, coupled with a 90-minute hybridization enables labs to now move from sample to sequencer in a single day.

Jul 18, 2017

Fluidigm Advanta Immuno-Oncology Gene Expression Assay

Fluidigm has launched the Advanta Immuno-Oncology Gene Expression Assay, a research-use-only qPCR assay that enables interrogation of tumor immunobiology using Fluidigm's microfluidic technology. Designed for use with the Biomark HD system, the assay detects 170 gene expression markers involved in checkpoint therapeutic response from FFPE and fresh frozen tumor samples. The assay can analyze biomarkers across defined T cell subsets, immune regulation, immune cell fate, cytokines, chemokines, and more, and can enable translational researchers to accelerate the development of checkpoint immunotherapies and to identify predictive biomarker signatures for therapeutic response.

Fluidigm said that the product is available as a two-panel set. The first panel includes 91 key markers of tumor immune response that were previously shown in a multicenter international clinical trial to inform tumor progression and checkpoint therapeutic response. The second panel includes 74 additional immuno-oncology markers and 17 open assay inlets for additional customization. Both panels contain the same five reference genes and can be purchased and used together or separately.

Jul 18, 2017

Empirical Bioscience 2X qPCR Probe Master Mix

Empirical Bioscience has released 2X qPCR Probe Master Mix for probe-based quantitative PCR applications. This new product is for real-time evaluation of DNA using fluorescent probe-based detection. It contains FlashTaq HotStart DNA polymerase, a chemically modified Taq DNA polymerase that remains inactive at room temperature but becomes activated after 2 minutes at 95° C. The master mix also contains dNTPs, MgCL2, and optimized buffer for fast, efficient qPCR. It has been optimized for use with hydrolysis-based probes such as TaqMan, but is also suitable with other probe-based detection systems. The mix is available in multiple versions for various applications including bulk and custom volumes for commercial and biotech.
Jul 18, 2017

Seraseq Circulating Tumor DNA v2 Reference Materials

SeraCare Life Sciences has launched a new set of ctDNA reference materials to aid development and validation of liquid biopsy assays. The new Seraseq Circulating Tumor DNA v2 reference materials were produced using a unique technology that produces a DNA fragment size-distribution which closely mimics native cfDNA, while decreasing DNA damage relative to ultrasonicated material, the company said.

The new product requires no special workflow considerations to generate informative data, and contains 40 somatic mutations, including important targets like BRAF V600E, KRAS G12D, and various EGFR alterations. Variants are present against a single well-characterized genomic background across a range of allele frequencies down to 0.125 percent, which ensures utility for assays with different limits of detection.

Jul 14, 2017

UCSF mNGS Test

The University of California, San Francisco's Center for Next-Gen Precision Diagnostics has launched a metagenomic next-generation sequencing test for neurological infections. Physicians can order the test for patients with idiopathic meningitis or encephalitis with unknown etiology. Testing is performed on cerebrospinal fluid. The testing process takes around 72 hours and results are reported back within one to two weeks. Charles Chiu, director of UCSF's Viral Diagnostics and Discovery Center, most recently described the test at a conference in February.

Jul 14, 2017

Biocept Progesterone Receptor Liquid Biopsy Test

Biocept has announced the commercial availability of its liquid biopsy test for progesterone receptor (PR), which can be used for the detection and monitoring of a key biomarker in the blood of patients with breast cancer. The company noted that the ability to detect PR expression in circulating tumor cells complements its existing ER and HER2 assays for biomarker analysis in breast cancer. Biocept's Target Selector PR expression test is performed on circulating tumor cells using fluorescently labeled antibodies. The company's liquid biopsy tests are performed in its CLIA-certified, CAP-accredited laboratory in San Diego.

Jul 12, 2017

Norgen Small RNA Library Prep Kit and Sequencing Services

Norgen Biotek, based in Ontario, has launched a Small RNA Library Prep Kit for Illumina sequencing instruments as well as sequencing services on Illumina instruments. The Small RNA Library Prep Kit needs between 0.5 nanograms and 1 nanogram of input RNA and can process samples from plasma, serum, blood, cerebral spinal fluid, urine, and exosomes, according to the company. Turnaround time is less than five hours. Norgen also offers complementary products, including NGS-compatible cel-miR-39 spike-in and an NGS library quantification kit. The services Norgen launched include isolation, library prep, sequencing, and bioinformatics. Sequencing can be performed on Illumina's MiSeq or NextSeq 500 instruments and includes small RNA-seq, RNA-seq, 16S metagenomics, targeted DNA or RNA sequencing, exome sequencing, and whole-genome sequencing.  

Jul 12, 2017

Exact Diagnostics Verification Panels

Exact Diagnostics launched its verification panels for IVD use. The panels include adenovirus; BKV; CMV; EBV; HBV; HCV; HHV-6A; HHV-6B; HIV-1; HSV-1; HSV-2; VZV; and Zika. They can be used to establish reference points to measure various analytes in molecular assays, the firm said. 

Jul 07, 2017

LGC High-Throughput Liquid Handling for PCR

LGC has launched the Meridian2 liquid dispensing system, a non-contact, on-the-fly dispenser suited to a wide range of dispensing applications, including reagents for genotyping and standard PCR. The Meridian2 features two plate positions for enhanced efficiency, integrated barcode reading, and automated assay mixing. It integrates into laboratories with existing SNPline automation or other Meridian instruments. The platform accurately dispenses 1-μL volumes into a 1,536-well plates in less than 45 seconds, with a CV of less than 5 percent, and the vacuum-based aspiration system allows multi-plate dispense for increased efficiency.

Jul 07, 2017

Li-Cor Biosciences D-DiGit Gel Scanner

Li-Cor Biosciences has launched the LED-based D-DiGit Gel Scanner, designed to help researchers eliminate the risk of ethidium bromide exposure and workspace contamination from their nucleic acid gel analysis experiments. The new system enables safe and convenient detection of DNA and RNA samples stained with fluorescent safe stains, like SYBR Safe, which are sensitive and environmentally friendly alternatives to ethidium bromide. Added either during gel preparation, or as a post-electrophoresis stain, safe stains eliminate the need for hazardous disposal and hassles associated with ethidium bromide. The D-DiGit improves protocol efficiency by consolidating nucleic acid analysis on a single system dedicated to high-sensitivity gel imaging. The scanner provides a large scan area to visualize most medium and larger format gels. Nucleic acid band extraction and imaging can be performed directly on the scan surface, the company said.

Jul 06, 2017

MDxHealth AssureMDx for Bladder Cancer Liquid Biopsy Test

MDxHealth has launched its AssureMDx for Bladder Cancer liquid biopsy test in the US as a laboratory-developed test. AssureMDx is a non-invasive, urine-based test. It searches for methylation and mutation biomarkers in order to assess the risk of bladder cancer for patients diagnosed with hematuria. The test's 93 percent sensitivity and 85 percent specificity can help doctors identify patients at increased risk for bladder cancer, who may benefit from cystoscopy, the company said. Testing will be conducted at MDxHealth's CAP- and CLIA-accredited lab in Irvine, California.

Jun 29, 2017

HTG Molecular Diagnostics GEP Assay

HTG Molecular Diagnostics launched the EdgeSeq Path Assay in the US and Europe. The assay is designed for retrospective gene expression profiling to complement immunohistochemistry testing. It allows investigators to assess mRNA expression of large numbers of biomarkers when there's limited availability of formalin-fixed, paraffin-embedded samples.

Jun 28, 2017

Canopy Biosciences Gene Expression Analysis Service

Canopy Biosciences has launched a service for high-throughput gene-expression analysis. Based on the NanoString nCounter platform, the service works with a large array of sample types, including formalin-fixed paraffin-embedded tissue. Canopy has paired this service with genome editing capabilities enabled by its recent licensing of TUNR flexible gene editing technology from Washington University in St. Louis and Johns Hopkins University. The new service features a web-based ordering tool, through which researchers can choose one of NanoString's pre-made gene panels or design their own custom panel. Each panel enables the simultaneous measurement of over 700 genes, Canopy said.

Jun 28, 2017

Roche Harmony NIPT 22q11.2 Deletion

Roche has added 22q11.2 deletion testing to the Harmony Prenatal Test menu, allowing laboratories and physicians using the test to screen for 22q11.2 deletion syndrome, which is associated with heart defects, poor immune system function, cleft palate, and delayed development. The 22q11.2 deletion is estimated to occur in one out of every 2,000 to 4,000 live births.

Jun 28, 2017

Bioarray PGS+PGD Single Biopsy Kit

Bioarray has launched its PGS+PGD Single Biopsy kit which screens aneuploidies and identifies embryos with pathological mutation from a single biopsy sample. The kit uses next-generation sequencing technology and bioinformatics analysis to determine whether an embryo carries aneuploidies, such as trisomy of chromosome 21, and allow for users to reject embryos affected by the mutation and/or select those not affected. Users can expect results to be processed within three to five days.

Jun 27, 2017

DNANexus Mosaic Microbiome Research Platform

Working with the Janssen Human Microbiome Institute, DNANexus has introduced Mosaic, a cloud-based informatics platform to support collaboration on research into the human microbiome. DNANexus is positioning Mosaic as a "virtual ecosystem and innovation accelerator" for academic medical centers, biotech and pharmaceutical companies, technology vendors, and government regulators.

Jun 27, 2017

SeraCare iQ NGS QC Management v2

SeraCare Life Sciences has launched version two of its iQ NGS QC Management software. The software supports laboratories' workflows from sample preparation to variant calling enabling lab managers to review and assess run performance, determine run pass or fail status, and identify potential sources of assay drift that could cause problems, according to the company. The software also generates a report that can be used for audits or inspections. The software integrates with existing data systems like Illumina BaseSpace and LIMS.

Jun 26, 2017

Oxford Nanopore PCR-cDNA and Direct cDNA Sequencing Kits

Oxford Nanopore Technologies has launched a PCR-cDNA Sequencing kit and a Direct cDNA Sequencing kit to prepare cDNA for nanopore sequencing. The PCR-cDNA kit requires a minimum input of 50 nanograms of RNA and the Direct cDNA kit requires at least 250 nanograms of RNA. Both kits can be used on any RNA with a polyA tail, and both are compatible with barcoding kits to multiplex samples.

Jun 26, 2017

Premaitha Health Updated Iona Test

Premaitha Health has updated its Iona noninvasive prenatal test, which now includes the first trimester combined test risk score as an option in its software. The company said that it completed a validation study to show that the Iona test in combination with the first trimester combined screen was as accurate as estimating prior risk using maternal age.

Jun 26, 2017

BloodCenter of Wisconsin's Diagnostic Laboratories hematology test panels

BloodCenter of Wisconsin's Diagnostic Laboratories launched seven hematology genetics test panels. The new panels include nonmalignant hematology disorders, such as platelet function disorders, inherited thrombocytopenia, and congenital neutropenias.  

Jun 22, 2017

Bio-Rad Droplet Digital PCR-Based Assays

Bio-Rad Laboratories has launched droplet digital PCR Genome Edit Detection assays, which can characterize edits generated by CRISPR-Cas9 or other genome editing tools. The assays use ddPCR technology which increases the signal-to-noise ratio, allowing users to quantify extremely rare edits, even those with frequencies of 0.5 percent and from as little as 5 nanograms of genomic DNA. Users can expect to obtain results within one day.

Jun 21, 2017

Children's Hospital Los Angeles OncoKids

Children's Hospital Los Angeles has launched OncoKids, a next-generation sequencing-based panel that detects mutations, gene amplification, and gene fusions for a full range of pediatric cancers including leukemias, bone and soft tissue tumors, and brain tumors. It only requires a small amount of DNA and RNA (20ng) isolated from fresh, frozen, or formalin-fixed paraffin-embedded tissue. The test was developed in collaboration with Thermo Fisher Scientific and uses the Ion Torrent S5 sequencing platform and Ion AmpliSeq technology.

Jun 19, 2017

Thermo Fisher Scientific ISQ EC Single Quadrupole Mass Spectrometer, MabPac RP 1mm Columns

Thermo Fisher Scientific has launched a new mass spectrometer and new chromatography columns. The ISQ EC Single Quadrupole mass spectrometer integrates with existing ion chromatography and HPLC systems, and the Chromeleon Chromatography Data Software has instrument control for the new mass spec embedded. The MabPac RP 1mm columns are designed for analyzing monoclonal antibodies, fragments, variants, antibody drug conjugates, and proteins using high-performance reversed-phase chromatography. They can operate with small sample volumes at low flow rates for direct injection into a mass spectrometer.

Pages

A phylogenetic analysis indicates two venomous Australian spiders are more closely related than thought, the International Business Times reports.

Technology Review reports that 2017 was the year of consumer genetic testing and that it could spur new analysis companies.

In Science this week: CRISPR-based approach for recording cellular events, and more.

A new company says it will analyze customers' genes to find them a suitable date, though Smithsonian magazine says the science behind it might be shaky.