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Feb 25, 2020

Twist Bioscience Comprehensive Exome Panel, Targeted Methylation Sequencing Solution

Twist Bioscience has launched its Twist Comprehensive Exome Panel, an optimal next-generation sequencing target enrichment solution that includes more than 99 percent of protein coding genes. The panel expands on the content of the Twist Human Core Exome to include coverage of protein-coding genes from all three key public genetic databases: CCDS, RefSeq and GENCODE, providing best-in-class coverage of the most up-to-date content, the company said. In addition, the panel can be customized quickly and affordably. Because of the updated and comprehensive coverage, the new panel allows for increased confidence in variant detection experiments, as well as maximum sequencing efficiency and best coverage uniformity.

Twist has also introduced the Twist Targeted Methylation Sequencing Solution to enable the study of methylation pattern changes in research fields including cancer, epigenetics, and non-invasive prenatal testing. The Targeted Methylation Solution offers a high-throughput, highly uniform target enrichment solution to explore methylation. This product is now available for early access customers, the company said. 

Feb 25, 2020

S2 Genomics Singulator 100 System

S2 Genomics this week launched the Singulator 100 System at the Advances in Genome Biology and Technology meeting. The Singulator 100 automates the processing of solid tissue samples into suspensions of single cells or nuclei with high yields and from small samples for a wide range of single-cell biology and genomic analyses. The company said that this enables researchers to reproducibly prepare suspensions of high-quality, highly viable cells or nuclei with minimal variability. The system will begin shipping in spring of this year with kits available for single-cell and nuclei isolation.

Feb 25, 2020

Lexogen RiboCop rRNA Depletion Kits for Bacteria

Lexogen has developed a set of new RiboCop rRNA Depletion Kits for bacteria, which it said efficiently removes 23S, 16S, and 5S rRNA from mixed bacterial samples and monocultures. According to the firm, RiboCop is offered as a standalone kit with the option to choose from three optimized probe mixes for depletion of either rRNA from mixed bacterial samples, or Gram-negative or Gram-positive bacteria grown in monoculture.

The technology uses a set of affinity probes designed for specific depletion of rRNA sequences, and, according to Lexogen, the probe design minimizes off-target effects that can distort NGS data quality. The kits work with total RNA input amounts as low as 1 ng and up to 1 μg, depending on sample composition and the chosen depletion probe mix. RiboCop does not include any enzymatic reactions or mechanical shearing steps and can process intact as well as degraded material, including FFPE, resulting in intact, full-length transcripts. Resulting rRNA-free samples are then suitable for a variety of downstream RNA analysis methods including RNA-seq library preparation approaches.

The protocol is also automation-friendly, the firm added.

Feb 25, 2020

Promega Wizard HMW DNA Extraction Kit

Promega has launched its Wizard HMW DNA Extraction Kit, a tool for researchers working with large fragments of genomic DNA. According to the company, the new HMW DNA product, which joins the firm's existing portfolio of both manual and automated kits to extract a variety of nucleic acids from a broad range of sample types, allows researchers, in a 90-minute manual protocol, to obtain DNA that can provide strong performance in long-read sequencing applications. Data on this performance was demonstrated in a poster presented at this week's 2020 Advances in Genome Biology and Technology (AGBT) meeting, Promega said. When run through a long-read sequencing protocol, the DNA from the Promega kit produced very long maximum reads and high N50 values, indicating a higher proportion of large fragments in the sample. 

Compared to available alternatives, Promega claimed that the Wizard kit purifies a "significantly higher" proportion of fragments over 125kb. The kit supports purification from a variety sample types including whole blood, bacterial cultures, cultured mammalian cells, and plant leaf tissue.

Feb 21, 2020

Bio-Rad Laboratories EDX RP Positive Run Control

Bio-Rad Laboratories said that Exact Diagnostics has launched the EDX RP Positive Run Control, an unassayed external quality control for monitoring the performance of clinical respiratory assays. Bio-Rad acquired Exact Dx in the third quarter of 2019. Routine use of the EDX RP Positive Run Control allows labs to meet their individualized quality control goals, such as the evaluation of reagent lot changes and new shipments, Bio-Rad said. The control also monitors multiple identical devices and provides an evaluation of different personnel and locations. It contains 22 respiratory analytes that are internally value-assigned using Bio-Rads Digital Droplet PCR technology and is designed to test the entire process of a molecular assay, including extraction, detection, and amplification. 

Feb 19, 2020

Covaris Viral RNA Extraction Kits

Covaris has launched two new kits for viral RNA extraction from nasal or throat swab sample collection devices. The truXTRAC Viral RNA Extraction kit uses Puritan swabs and contains all components for the firm's adaptive focused acoustics-based extraction as well as magnetic bead-based purification of high-quality RNA from synthetic swabs. The truXTRAC-PCR Direct Viral RNA Extraction kit can be used directly in real time RT-PCR assays without prior purification, provided an internal control is included.

Feb 19, 2020

Integrated DNA Technologies xGen Prism DNA Library Prep Kit

Integrated DNA Technologies (IDT), a Danaher company, has launched the xGen Prism DNA Library Prep Kit, which is designed for challenging and low-quality samples. The kit can convert cell-free DNA and DNA from formalin-fixed paraffin-embedded tissue into high-quality next-gen sequencing libraries. It greatly reduces adapter dimers and uses unique molecular identifiers (UMIs) for enhanced error correction.

Feb 18, 2020

Thermo Fisher Scientific Applied Biosystems PowerTrack SYBR Green PCR Master Mix

Thermo Fisher Scientific has released the Applied Biosystems PowerTrack SYBR Green PCR Master Mix. It is designed for real-time PCR workflows and is compatible with all qPCR instruments. It contains a two-color tracking dye system to help researchers keep track of where they have pipetted. The mix uses an antibody-mediated hot-start mechanism to control activation of the Taq enzyme. It also includes UNG and dUTP enzymes to prevents previously amplified PCR products from contaminating subsequent qPCR reactions. The mix provides results ranging from 0.1 pg to 100 ng of complementary DNA per reaction and can be used in standard or fast cycling mode.

Feb 18, 2020

Nebula Genomics 30X Whole-Genome Sequencing Service

Nebula Genomics has launched a new, direct-to-consumer whole-genome sequencing service. Performed with MGI DNBSEQ T-Series instruments in BGI's global network of sequencing centers, Nebula's service offers 30X coverage for $299.

Individuals who sequence their genome through Nebula will retain full control of their genomic data, the firm added in a statement.

Feb 13, 2020

PerkinElmer Sciclone G3 NGSx HT Workstation

PerkinElmer has launched the Sciclone G3 NGSx HT Workstation for automated next-generation sequencing library preparation. The instrument comes with a 384-plex low-volume pipetting head, on-deck thermal elements, a shaker, a thermal cycler, and a robotic pipette tip loader. It can automate cDNA synthesis from RNA or single cells as well as library construction from cDNA or gDNA. DNA-seq libraries can be prepared using the Nextflex Rapid XP DNA-seq kit.

Feb 11, 2020

Living DNA African Ancestry DNA Test Report

Living DNA, a direct-to-consumer genealogy DNA service, has launched an African ancestry DNA test report that covers 72 regions in Africa. Living DNA said that its report offer five times the African ancestry coverage of any other test, and has been specially designed for African Americans and African Europeans who are researching their roots. The test combines recent ancestry breakdown (last 1,000 years) with deep direct maternal and paternal histories, as well as rich information about the regions from which customers' ancestors originate, covering geography, languages, traditions, and culture. All existing customers with African ancestry can log into their results platform and choose to update their results free of charge, the company said. New customers can purchase a test on offer for Black History Month for $79.

Pages

A study of families explores how children transmit SARS-CoV-2, according to the Associated Press.

US Agricultural Research Service scientists have sequenced the genome of the Asian giant hornet.

According to the Economist, pooled testing for COVID-19 could help alleviate strains on testing labs.

In Science this week: MIT researchers outline approach dubbed translatable components regression to predict treatment response among IBD patients.