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Jul 02, 2019

ZeptoMetrix NATtrol Respiratory Verification Panel

ZeptoMetrix has released the NATtrol Respiratory Verification Panel, a 20-member respiratory panel for use by laboratories in QC applications with molecular diagnostics for infectious disease testing. ZeptoMetrix was founded in 1999 and is based in Buffalo, New York.

Jul 01, 2019

Cellecta Dual-sgRNA Libraries

Cellecta has commercially launched its dual-sgRNA libraries designed for CRISPR activation (CRISPRa) and CRISPR interference/repression (CRISPRi) genetic screens. With the modified systems, the firm said it has re-engineered the standard knockout capacity to modulate gene activitiy. The variations extend the types of genetic screenings possible. 

According to Cellecta, its dual-sgRNA CRISPRa and CRISPRi libraries improve single-sgRNA library activity because each construct expresses two different sgRNA binding distinct sites on the promoter of each gene target. The firm believes this advantage increases the likelihood that each targeted gene will be activated or repressed above a given threshold when compared to libraries that only have a single sgRNA targeting a gene promoter. 

Jun 28, 2019

23andMe MUTYH-Associated Polyposis Report

23andMe has launched a new genetic health risk report for MUTYH-Associated Polyposis (MAP), one of three main hereditary colorectal cancer syndromes. According to the firm, the report examines two genetic variants in the MUTYH gene, Y179C and G396D, associated with MAP. The firm will offer the report to new Health + Ancestry Service customers as well as existing 23andMe Health + Ancestry Service customers genotyped on its most recent platforms.

Jun 28, 2019

BillionToOne Unity Prenatal Screen

BillionToOne has commercially launched its Unity prenatal screening assay. According to BillionToOne, the assay is powered by its molecular counting technology and is the only prenatal screen that tests cell-free fetal DNA for cystic fibrosis, spinal muscular atrophy, and sickle cell disease using only one tube of the mother's blood. The firm said it will make the test available at select clinics through its early access program, with plans for a broader commercial launch later this year. 

Jun 26, 2019

AutoGen Xtract 16+

AutoGen has launched its Xtract 16+ system, which it said provides fast and high-quality DNA or RNA from molecular diagnostic, biological, clinical, and forensic sample types. According to AutoGen, the instrument can simultaneously process between 1-16 samples. The Xtract 16+ also provides full traceability of kits and samples through real-time, app-based monitoring, which automatically generates reports for LIS/LIMS. 

Jun 26, 2019

Thermo Fisher Scientific Invitrogen Collibri DNA Library Prep Kits

Thermo Fisher Scientific has launched several Invitrogen Collibri DNA Library Prep kits for use with high-throughput Illumina sequencing systems. The kits contain a tracking dye to visualize the library prep process and to show that reagents have been properly mixed. The dyes do not interfere with enzymatic reactions and do not affect the sequencing results. Four versions of the kit are available, for either physically sheared or enzymatically sheared DNA, and involving either PCR or no PCR. All kits contain adapters with unique dual indexes or combinatorial dual indexes that enable up to 24 or 96 samples to be pooled for sequencing.

Jun 26, 2019

Porvair Sciences Drosophila ChIP Kits

Porvair Sciences has launched its commercial ChIP kit range dedicated to Drosophila. The new kits deliver high-quality ChIP-ready chromatin from tissue from as little as five Drosophila specimens. According to Porvair, the new kits offer improved sensitivity. The new Chromatrap range includes Drosohila UniqSeq, ChIP-Seq, Antibodies, and Primer Sets. 

Jun 26, 2019

Expedeon Lightning-Link Metal Labeling Kits

Expedeon announced this week that it has introduced Lightning-Link Metal Labeling Kits for multiple immunoassay-based applications to support single cell analysis. According to Expedeon, the new kits will allow users to enhance the phenotypic analysis of heterogeneous cell populations, providing increased multiplexing capability compared to fluophore labeling, improved sample throughput, and research output. The firm also noted that the labeling kits only require about 30 seconds of hands-on time. 

Jun 25, 2019

GenScript Enhanced GenBrick Gene Synthesis Service

GenScript has launched an upgrade to its GenBrick Gene Synthesis platform, which gives researchers access to DNA sequences up to 200 kilobases long with 100 percent accuracy. GenScript said it has optimized the genome assembly process and enhanced its technology to better handle difficult sequences. It has also developed new technology to quickly and accurately create long DNA sequences in one step that are free of any mutations or negative clones. 

The GenBrick service has been tested and used in synthetic biology projects such as the Synthetic 2.0 Yeast Genome (Sc2.0) project, where it synthesized the long arm of yeast chromosome VI. 

Jun 24, 2019

Phitonex NovaFluor Dyes

Phitonex has launched a new suite of NovaFluor dyes, which the firm said allows researchers to rapidly increase the number of scientific questions they can answer per cell on extant flow cytometry instrumentation. According to Phitonex, the platform helps engineer optical properties to provide high resolution single cell analysis with flow cytometry. 

Jun 20, 2019

Phase Genomics ProxiMeta Platform

Phase Genomics has launched its new ProxiMeta platform, which includes a 8-pack ProxiMeta kit with cloud-based ProxiMeta Analysis. According to the firm, the platform allows users to assemble hundreds of genomes and associated plasmids, phages, and antibiotic resistance, and interactions between genetic elements in microbial cells and communities. Phase said that the eight-reaction kit uses improved chemistry, includes reagents needed to prepare a sequencing-ready library from a microbiome sample, and does not require specialized equipment.

According to the firm, applications include antimicrobial resistance genes discovery, capturing phage and horizontal gene transfer, understanding the relationship between the microbiome and the resistome, and high-quality metagenome assembly from microbiome samples.

Jun 19, 2019

Cytek Biosciences Aurora Flow Cytometer

Cytek Biosciences is launching the latest version of its Cytek Aurora flow cytometry system featuring five lasers and the ability to detect more than 30 colors from a single sample without changing optical filters. The system can be used with any fluorochromes excited by the onboard lasers, and offers high resolution of dim and rare populations, Cytek said. The system simplifies workflows, saves costs, and allows access to a greater choice of dyes and specificities for applications that require deep profiling of cell populations in a single sample, the company added.

Jun 19, 2019

BGI 676 Quality Genome Standard

BGI has introduced the 676 Quality Genome, a new standard and cost-effective solution for high quality de novo genome assembly using MGI's DNBSEQ and stLFR technologies. BGI defined the standard as having a contig N50 greater than 106 bases (>1Mb), scaffold N50 greater than 107 bases (>10 Mb), and, for the human genome, total assembled size larger than 6 Gb. The firm expects the standard's cost to be $1,000, on the upcoming MGISEQ-T7 sequencing platform.

According to BGI, the 676 Quality Genome can detect all types of structural variants and is ideal for assembling regions of the genome not well represented by the reference genome. The firm said that the 676 Quality Genome provides more accurate and comprehensive genetic predictions, since it assembles each person's genome individually and does not depend on a reference genome.

Jun 18, 2019

Biocept NGS Breast Panel

Biocept has launched its second multi-gene liquid biopsy product, the Target Selector NGS Breast Panel, which is run on Thermo Fisher Scientific's Ion Torrent next generation sequencing platform and is designed to enable the detection and monitoring of actionable genomic biomarkers associated with breast cancer. The company said the test, which will be marketed to physicians and researchers, has shown over 99 percent sensitivity with at least 90 percent specificity in internal validations. 

Jun 17, 2019

Qiagen Microbial Insights AR

Qiagen has launched Microbial Insights AR (QMI-AR), an integrated genomic database that provides curated, single-point entry access to four of the world's largest knowledgebases on antimicrobial resistance. Specifically, it integrates the Comprehensive Antibiotic Resistance Database (CARD), ResFinder, a National Institutes of Health AMRFinder database of resistance genes, as well as the ARG-ANNOT database of peptide markers. According to Qiagen, the database complements ARESdb, a comprehensive, regularly updated genomic knowledgebase on clinically relevant antibiotic resistance strains that the firm has made available to the global research community through a partnership with Ares-Genetics, a Curetis subsidiary. Qiagen said that it will offer QMI-AR through the CLC Microbial Genomics Module, an extension to the CLC Genomics Workbench bioinformatics software.

Jun 17, 2019

GeneCast RUO Kits

South Korea-based liquid biopsy firm GeneCast has launched a set of research-use-only kits for BRAF, EGFR, and JAK2 mutation detection. The firm claims technical sensitivity for the BRAF assay as low as 0.0001 percent, and for the EGFR and JAK2 kits of 0.01 percent. The products use the company's ADPS quantitative PCR method, and the firm said it is working on gaining approval to offer the products for clinical use, filing a PMA submission with the US Food and Drug Administration, for the EGFR assay for example. GeneCast plans to launch additional RUO kits for KRAS, NRAS, PIK3CA, pTERT, IDH1, and IDH2 by the end of this year.

Jun 17, 2019

Twist Bioscience Mouse Core Exome Panel

Twist Bioscience has launched the Mouse Core Exome Panel for target enrichment in next-generation sequencing. The comprehensive panel for research use is built from the most current databases.

Jun 17, 2019

Paragon Genomics CleanPlex NGS Panels

Paragon Genomics has launched a series of CleanPlex products for MGI sequencers. The firm now offers its CleanPlex for MGI Ready-to-Use NGS panels, which can be used for both MGI's OncoZoom Cancer Hotspot Panel and MGI's BRCA1 and BRCA2 Panel. Paragon also offers its CleanPlex for MGI Custom NGS panels, which allow researchers to build customized assays to address specific needs. The firm noted that its support staff will take custom orders, developing and delivering panels that are completely compatible with MGISEQ sequencers. In addition, Paragon is offering validated automation protocols ensuring that CleanPlex for MGI assays can work with the MGISP-960 Automated Sample Preparation System to produce the same results performed if done manually. 

Jun 14, 2019

BGI Whole Exome Sequencing Service

BGI Genomics has launched a clinical research whole exome sequencing service called BGI-Xome, which incorporates clinical interpretation services from UK-based Congenica. BGI will perform WES at its service laboratories, while interpretation will be completed by clinical scientists using the Congenica clinical decision support platform. According to BGI, Congenica's Interpretation platform will allow its service to provide a "gold-standard" and effective solution that eliminates the risk of users missing or misidentifying disease-linked mutations. 

Jun 13, 2019

Oxford Gene Technology SureSeq NGS Library Prep Kit

Oxford Gene Technology has released a new SureSeq library preparation kit for hybridization-based target capture in next-generation sequencing. According to the firm, the kit offers a streamlined protocol with enrichment by hybridization with a ready-to-use hybridization and wash buffer. It also reduces manual handling steps to increase reliability and throughput. The firm also said that the kit lowers duplication rates, leading to more accurate calling and more even coverage.

Jun 12, 2019

Patients Choice Laboratories UTI+ Test

Patients Choice Laboratories has launched the UTI+ molecular test for urinary tract infections. The Indianapolis-based company said the new test is part of its goal to be a full-service lab. It added that its gene- and molecular-based technologies provides uropathogenic and antibiotic resistance testing results within six hours after specimen receipt compared to up to three days with urinalysis by culturing. 

Jun 11, 2019

Genestack Omics Data Manager

Genestack has introduced Omics Data Manager, a system for cataloguing, curating, indexing, searching, and sharing multi-omics data. Omics Data Manager can serve as centralized repository for enterprises looking to implement the FAIR (Findable, Accessible, Interoperable, and Reusable) principles for biomedical data management. Omics Data Manager can be integrated into laboratory information management systems and third-party, upstream data analysis platforms, according to Cambridge, UK-based Genestack. 

Pages

GenomeWeb reports that Veritas Genetics is suspending its US operations.

A Brazilian-led team of researchers reports it has generated a sugarcane genome assembly that encompasses more than 99 percent of its genome.

Certain plasma proteins could be used to gauge a person's age and whether they are aging well, according to HealthDay News.

In Science this week: approach to measure microRNA targeting efficiency, strategy to conduct high-throughput chemical screens at single-cell resolution, and more.