Close Menu

New Products

Feb 05, 2019

Saphetor VarSome Pro

Saphetor released VarSome Pro, a paid, enhanced version of the free VarSome genomic annotation software tool aimed at researchers. The Swiss company said that VarSome Pro features advanced variant filtering and annotation of whole VCF files for single and multiple samples, gene panels, exomes, and genomes. Saphetor also recently rebranded its Saphetor Portal next-generation sequencing interpretation platform as VarSome Clinical. 

Feb 04, 2019

Oxford Nanopore Technologies Direct cDNA (SQK-DC109), PCR-cDNA (SQK-PCS109) Kits

Oxford Nanopore Technologies has launched two new cDNA sequencing kits for its nanopore devices. The kits, called Direct cDNA (SQK-DC109) and PCR-cDNA (SQK-PCS109), generate sequence data for full-length cDNA and require less than five hours of sample preparation. The Direct cDNA kit does not require PCR and needs 100 ng of poly-A+ RNA. The PCR-cDNA kit has an input requirement of just 1 ng of polyA+ RNA and can start from total RNA. Users can obtain 10 to 15 million reads on a MinIon flow cell and more than 60 million reads on a PromethIon flow cell. According to the firm, the kits are available for the MinIon, GridIon, and PromethIon sequencers.

Feb 04, 2019

Viracor Eurofins Baloxavir marboxil (Xofluza) Influenza A Antiviral Resistance PCR

Viracor Eurofins has launched its test for resistance to the antiviral Xofluza (baloxavir marboxil). The Baloxavir marboxil (Xofluza) Influenza A Antiviral Resistance PCR detects I38T/M/F mutations in H3N2 and 2009 H1N1 strains of influenza A and aids in evaluating resistance to the drug developed by Shionogi and Roche. Results can be available to healthcare providers within eight to 12 hours from the receipt of nasopharyngeal swab at Viracor's lab, the company said. 

Feb 04, 2019

Ncardia DiscoverHit Drug Screening Platform

Ncardia has launched the DiscoverHit drug screening platform, a service intended to help researchers access disease-relevant biology earlier in the drug-discovery process. DiscoverHit is a phenotypic drug screening platform comprising genetic and induced human pluripotent stem cell-derived cardiac and neural disease models; controlled bioreactor-based manufacturing to enable batch sizes compatible with high-throughput screening; customized development of disease-relevant assays; and high-throughput screening combined with high-content data acquisition and analysis.

Feb 04, 2019

Fluidigm REAP-Seq Protocol for C1 System

Fluidigm has introduced a REAP-seq (RNA expression and protein sequencing) protocol for use with its C1 sample prep system for single-cell genomics. C1 REAP-seq enables characterization of unique cellular subtypes and functional states by measuring the expression of both cellular proteins and RNAs. Users can pair the protocol with functional imaging assays that measure differences in cell size, morphology, or phenotype within the clear C1 microfluidic cell chambers. The firm developed C1 REAP-seq in collaboration with Merck for co-detection of both cellular protein and RNA using microfluidic technology.

Feb 04, 2019

Genoox AI, Data Aggregation

Genoox has updated its technology platform to include artificial intelligence to process new clinical evidence in an effort to "promote regular and periodic genomic data reanalysis and data aggregation to quicken diagnoses for patients," the company said in a statement. The update is intended to help clinicians improve diagnostic yield.

Jan 28, 2019

Biocept Target Selector Kits

Biocept has announced the availability of the first research-use-only (RUO) assay in a planned menu of kits for labs to run its Target Selector circulating tumor DNA assays in house.  The first assay being released is for high-sensitivity detection of EGFR mutations, which are among the most frequently evaluated biomarkers for lung cancer. Additional RUO test kits for other oncogene mutations are planned for launch in the future.

All will use Biocept's proprietary "switch blocker" technology, which the firm says produce industry-leading sensitivity for the detection of variants of interest. The EGFR kit and other assays can be used on a variety of analytical platforms including qPCR, Sanger sequencing, microarrays, mass-spectrometry, and next generation sequencing. 

Jan 24, 2019

Oxford Nanopore PromethIon 24, PromethIon 48

Oxford Nanopore Technologies said this week that its PromethIon 24 and PromethIon 48 sequencing platforms are now available for users to order. The instruments can run up to either 24 or 48 flow cells, respectively, and include a computer for real-time data analysis. The run time ranges from 1 minutes to 64 hours, and the best yield per run with 1D reads so far has been 7.6 terabytes, based on customer data, with a theoretical maximum of 15 Tb. There is no instrument cost, but users must pay for a $20,000 annual service contract. Flow cells range in price from $625 to $2,000, depending on order type and volume, and reagent costs per run are $99.

Jan 22, 2019

Intermountain Healthcare Precision Genomics ICG100 Myeloid Malignancies Panel

Intermountain Healthcare Precision Genomics has announced its ICG100 Myeloid Malignancies Panel to help classify and diagnose multiple blood cancer types. The panel includes 63 genes and uses peripheral blood, bone marrow aspirate, extracted DNA, or fixed samples to detect faulty gene alterations through next-generation sequencing. According to the firm, the panel identifies variants in genes linked to several cancers, including acute myeloid leukemia, myeloid proliferative neoplasm, myeloid dysplastic syndrome, and myeloid dysplastic/myeloid proliferative overlap disorders. 

Jan 22, 2019

AusDiagnostics Dermatophytes IVD Kit

AusDiagnostics has released a new in vitro diagnostic kit that detects dermatophytes and other fungi. According to the firm, the new kit will produce a result in four hours, allowing medical professionals to advise their patients on the best course of treatment. AusDiagnostics said that the kit detects species of Microsporum, Trichophyton, and Epidermophyton, as well as identifying six common dermatophytes and six Candida species. 

Jan 22, 2019

Horizon Discovery CRISPR Screening Service for Primary Human T Cells

Horizon Discovery has extended its CRISPR Screening Service to include ex vivo T lymphocytes. Horizon has adapted its established CRISPRko (knockout) platform to screen human T lymphocytes, adding CRISPRko screens in ex vivo T lymphocytes to its established CRISPR screening formats – CRISPRko, CRISPRi (interference) and CRISPRa (activation) – in cancer cell lines. The service extension meets the requirements of immunology-based research in drug discovery, allowing for the identification of new gene targets in biologically and potentially therapeutically relevant settings, the firm said.

Jan 16, 2019

HTG Molecular EdgeSeq Reveal

HTG Molecular today launched its HTG EdgeSeq Reveal software. According to the firm, the software streamlines biomarker data analysis from samples analyzed with the HTG EdgeSeq Precision Immuno-Oncology Panel on its EdgeSeq system. When used with the panel, the software allows applications including immunophenotyping of tumor infiltration lymphocytes, monitoring of immunotherapy response biomarkers, and elucidating immune-escape mechanisms know to drive disease progression. The firm noted that users will be able to conduct molecular profiling using a wide variety of sample types, potentially allowing them to support translational applications and determine potential biomarkers for companion diagnostic development. 

Jan 16, 2019

Oxford Nanopore Field Sequencing Kit

Oxford Nanopore Technologies has launched a Field Sequencing Kit for sequencing library preparation from genomic DNA that requires no refrigeration. The kit requires 400 nanograms of high molecular weight DNA as input, and generates libraries in 10 minutes using a two-step protocol. A transposase simultaneously cleaves template molecules and attaches tags to their ends. After that, rapid sequencing adapters are added to the tagged ends. The unopened kit is shipped cold and is stable for up to one month at 30° C and up to three months at 2° C to 8° C.

Jan 14, 2019

NRGene, Macrogen ArrayMagic

NRGene and Macrogen have launched a joint sequencing-based genotyping service called ArrayMagic, which the firms said provides ultra-high-density SNP genotying at a low cost per datapoint. As part of the service, the team will launch a dedicated website to advise customers on how to send samples to Macrogen. The partners then employ a sequencing library prep method, developed by iGenomX, to create an ultra-low coverage sequencing dataset for each sample. NRGene then applies its database and analytical tools to impute a high-resolution SNP set from the data. 

Jan 11, 2019

TATAA Biocenter Alu Assays

TATAA Biocenter is now offering ultra-sensitive qPCR assays targeting human-specific Alu repeats, which comprise about 10 percent of the human genome. The assays are available for different target lengths, which makes it possible to characterize the integrity of gDNA. The ration measured with TATAA ALU-60, which amplifies 60-bp targets, to TATAA ALU-187, which amplifies 187-bp targets, assesses the level and fraction of cell-free DNA in liquid biopsy samples. The assays can detect even miniscule amounts of human genomic DNA contamination, and contaminated reagents can be cleaned with the Heat/Run gDNA removal kit. The ALU quality control panel was in part developed for the CANCER-ID consortium, TATAA said.

Jan 09, 2019

Asuragen AmplideX PCR/CE HTT Kit

Asuragen said today that it has launched its AmplideX PCR/CE HTT kit. The tool detects CAG trinucleotide repeats within the HTT gene, which are linked to the development of Huntington disease. According to the firm, the kit offers a streamlined, single-well PCR workflow that allows researchers to detect and size expansions with greater than 200 CAG repeats in about six hours. The kit provides all necessary reagents to size the expansion using 10 ng of DNA isolated from whole blood samples. The assay also addresses sample zygosity and preserves the CAG repeat profile in the presence of adjacent SNPs. The assay runs on Thermo Fisher Scientific Applied Biosystems Genetic Analyzers, including the 3130, 3500, and 3700 platforms.

Jan 08, 2019

Yourgene Sage 32 Plex

Yourgene Health has launched the Sage 32 plex test, a high-throughput noninvasive prenatal testing and analysis solution for clinical laboratories. It runs on Thermo Fisher Scientific's Ion Torrent sequencing platform and allows 32 samples to be processed in parallel. The test, which will be available internationally, has improved performance due to workflow enhancements and upgraded analysis methods. Yourgene plans to launch a CE-IVD-marked version of the library preparation kit for the Sage 32 plex workflow in the coming months. The Sage test differs from Yourgene's other NIPT, the Iona test, in that it screens for a wider range of conditions, including trisomies 21, 18, and 13; sex chromosome aneuploidies; and clinically relevant microdeletions. The analysis uses a cloud-based bioinformatics solution called Sage Link.

Jan 07, 2019

Twist Bioscience Synthetic DNA, TAPI

Twist Bioscience is now offering to synthesize genes up to five kilobases in length for $0.15 per base pair and with a turnaround time of 15 to 25 days. In addition, the company is making its Twist Application Programming Interface (TAPI) available to all customers ordering synthetic DNA.

Jan 04, 2019

PreventionGenetics Patient Plus

PreventionGenetics announced that it has added the Patient Plus feature to its PGxome whole-exome sequencing tests. Patient Plus invovles sequencing and copy number variant analysis, as well as targeted testing for the key sequence variants in a patient's parental specimens. According to PreventionGenetics, the approach allows researchers to detect de novo variants and phasing of variants in recessive genes.

Pages

New US Department of Commerce rules will affect supercomputing in China, according to the Wall Street Journal.

A new analysis finds that it will be more than a century until female computer scientists publish at the same rate as their male counterparts, ScienceInsider reports.

Broad Institute researchers describe an approach they've dubbed "DNA microscopy."

In PLOS this week: epigenetic changes following hepatitis C virus treatment, metagenomic analysis of Ugandan children with febrile illness, and more.