Close Menu

New Products

Mar 11, 2019

23andMe Type 2 Diabetes Report

Consumer genetics company 23andMe on Sunday launched a Type 2 Diabetes Report that tells customers if they are at risk of developing the disease and the lifestyle changes that could make a positive difference. "The report can help customers learn how their genetics, along with other factors such as their weight, age and lifestyle, may influence the likelihood of developing type 2 diabetes, as well as actions they can take to lower that likelihood," 23andMe said in a blog post.

Unlike the company's other genetic health risk tests, which tell customers if they have specific disease-linked SNPs, the type 2 diabetes test employs a polygenic risk score (PRS) that combines more than 1,000 SNPs in an algorithm. This latest test has not been approved or cleared by the US Food and Drug Administration in contrast to the firm's earlier genetic health risk tests.

23andMe said it developed and validated the PRS using the real-world data of 2.5 million customers who have opted to donate their genetic and phenotypic information to research. In a white paper, the company notes that the type 2 diabetes PRS was developed on variants from genome-wide association studies involving people of European ancestry, and that it trained the score on Europeans and recalibrated for other populations. The data show that the score works best in those of European ancestry and doesn't work as well in African American populations.

Mar 07, 2019

LGC, Biosearch Technologies RapiDxFire Thermostable RT

LGC, Biosearch Technologies has launched RapidDxFire Thermostable RT, a thermostable reverse transcriptase designed specifically for diagnostic kit developers. The enzyme's optimum temperature of 55° C to 80° C improves reaction specificity and allows synthesis from diverse RNA templates. It also has a reaction time of five minutes or less, and is recommended for targets under 1 kb. Its extended stability at room temperature make it compatible with automation, and the enzyme is available in a lyophilization-ready Triton X-100-free format, the company said.

Mar 07, 2019

BioIVT Xpressway Profile Safety Package

BioIVT has launched the Xpressway Profile Safety Package, a compendium of 46 expression profiles for genes known to play pivotal roles in drug safety assessments. These genes are included in the initial screening panel used by pharmaceutical companies to evaluate new chemical entities for potential off-target interactions and toxic effects. Once these entities have been screened against the 46 target genes, the Xpressway Profile Safety Package allows the resulting binding data to be compared with the corresponding human target expression profiles and interpreted further to assess potential safety risk, the company said. When NCEs bind to the targets, the tissue distribution of those targets can inform decision making about the compounds and chemical series. BioIVT said that it employed a rigorous, highly controlled qRT-PCR method to develop the Xpressway Profile Safety Package's gene expression data.

Mar 06, 2019

IDT rhAmpSeq Targeted Sequencing System

Integrated DNA Technologies (IDT) has launched the rhAmpSeq targeted sequencing system. The proprietary rhAmpSeq chemistry enables highly multiplexed target amplification for sequencing on Illumina platforms with high on-target rates and uniform coverage. Its applications include human disease research, sample tracking and analysis, CRISPR genome editing analysis, and agricultural biotechnology. The system makes use of IDT's RNase H2 PCR technology, employing an RNase H2/DNA polymerase enzyme system coupled with RNA-DNA hybrid primers. It has been optimized for panel sizes from tens to thousands of amplicons in a single reaction.

Mar 06, 2019

Beckman Coulter Apostle Minimax High Efficiency Cell-Free DNA Isolation Kit

Beckman Coulter has launched the Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit through an exclusive partnership with liquid biopsy firm Apostle. The tool is a magnetic nanoparticle-based kit that extracts cfDNA from plasma using manual or automated workflows. According to the firm, the kit performs reliably across a range of volume inputs while consistently recovering high quantities of cfDNA and effectively removing contaminants. 

Mar 05, 2019

Loop Genomics mRNA Transcript Counting and Phasing

Loop Genomics has launched a kit and service for mRNA transcript counting and phasing using its synthetic long-read technology that works in conjunction with next-generation sequencing on Illumina instruments. The kit costs $70 per sample and the service $299 per sample. The San Jose, California-based startup, uses unique molecular identifiers and enzymes to attach the same barcode at multiple positions along one long molecule.

Mar 01, 2019

Twist Bioscience Target Enrichment Products

Twist Bioscience has launched several new products for its Twist Human Core Exome Kit and Twist Custom Panels NGS target enrichment workflows. The products include Twist Fast Hybridization and Wash Kit, Twist Universal Blockers that allow flexible blocking and improved on-target capture, the Twist Universal Adapter System that maximizes performance for library preparation, and the Twist Mechanical Fragmentation Library Prep Kit for highly-degraded samples. According to the firm, the products will accelerate hybridization to about 15 minutes and will seamlessly integrate into any automation workflow.

Mar 01, 2019

Lexogen Corall Whole Transcriptome Library Kit

Lexogen has launched its Corall Total RNA-Seq Library Prep Kit. The firm said that researchers can use the kit for all whole-transcriptome analysis applications, including differential expression, isoform quantification, and single nucleotide polymorphism and mutation detection. Lexogen highlighted that Corall can use as little as 1 nanogram and up to 1 microgram of total RNA. The kit integrates unique molecular identifiers that facilitate the identification and removal of PCR duplicates, while ensuring high strand specificity. The kits include up to 96 i7 indices for sample multiplexing. Researchers can also add i5 indices for a total of 9,216 indexing combinations. The firm offers the kits in in 24 and 96 prep sizes, as a standalone library preparation kit, or in combination with with the RiboCop rRNA Depletion Kit.

Mar 01, 2019

Furukawa Electric Single Cell Hunter

Furukawa Electric has launched the Single Cell Hunter, a microchip-based automated live cell high-throughput screening system. Single Cell Hunter analyzes live cells on a microchip within a temperature-adjustable chamber to catch the responses of stimulated cells under near-physiological conditions and identify them in a time-lapse mode, which enables accurate evaluation of the real potential of each cell. The system features standard, pre-coated microchips for dynamic identification and recovery of fluorescence-labeled cells, or for fluorescence-linked immunosorbent assays for the identification of the cells that have an ability to secrete antibodies or specific antigen proteins. The platform also features multi-color screening, and AI-based high-precision cell-friendly pick-up and drop-off technology, which enables recovery of even a single yeast cell as small as 3 μm in diameter from a 10-μm microwell.

Mar 01, 2019

Bionano Genomics Saphyr Chip, Sample Prep, Data Analysis

Bionano Genomics this week released new products related to its Saphyr platform for structural variation detection in genome analysis. First, the company launched a new version of the Saphyr Chip with three independent flowcells. When running on the two-chip Saphyr platform models that ship in 2019, the 3 X 1300 Saphyr Chip allows customers to map up to 42 whole human genomes per week or collect 1,300 Gbp (400x) coverage in less than 48 hours for samples in each of three flowcells.

The company also released a new kit for DNA isolation from blood and cells called Bionano Prep SP (solution phase). According to the company this kit dramatically reduces the time and effort needed to obtain extremely long, ultra-high molecular weight DNA by eliminating steps like plug-lysis and drop dialysis. Bionano Prep SP enables users to manually process up to six patient samples in less than three hours or up to 12 patient samples per day, which reflects a savings of a full day from the workflow compared to the current plug-lysis approach, Bionano said. The new kit also costs less on a per-sample basis, the protocol is automatable, and the high purity of resulting DNA enables faster run times on the instrument and higher data quality, the company noted.

Bionano also announced the upcoming release of the latest version of Bionano Solve, its suite of data-analysis tools, which for the first time will be available in a cloud-based implementation called Bionano Compute On-Demand. The pipeline analyzes single molecules for structural variation detection at low-allele fractions, and is particularly suited for analysis of complex, heterogeneous cancer samples and samples with germline mosaicism, the company said. All major types of structural variation can be detected with more than 80 percent sensitivity when present in just 5 percent allele fraction, while translocations and inversions can be detected with more than 90 percent sensitivity at this low frequency.

Feb 28, 2019

Agilent Magnis NGS Prep System

Agilent has launched the Magnis NGS Prep System, a fully automated next-generation sequencing library preparation system. The firm has designed the platform to help researchers easily assay multiple genes and complex genetic aberrations from genomic DNA, including degraded samples such as formalin-fixed, paraffin-embedded specimens, Agilent said. The system comes with pre-aliquoted reagents and pre-set protocols, and is fully compatible with Agilent's SureSelect [XT HS] library prep workflow. The system can provide reproducible results with a one-day turnaround time, Agilent noted.

Feb 27, 2019

Dolomite Bio scRNA-Seq Reagent Kit

Dolomite Bio has launched its new scRNA-Seq Reagent Kit, which the firm said will expand the Nadia instrument portfolio. Dolomite said it has designed the kit to allow reliable and robust generation of PCR-amplified cDNA libraries on its Nadia instrument, allowing researchers to achieve reproducible datasets at low sequencing costs. The firm said that the set up also allows users to adjust the number of single cell cDNA libraries prior to sequencing, which it believes will ensure cost-efficient single cell analysis.

Feb 22, 2019

Stratec Molecular InviMag FFPE DNA Kit

Stratec Molecular has launched its InviMag FFPE DNA kit, which the firm said allows efficient, fully automated purification of pure and PCR inhibitor-free DNA from formalin-fixed, paraffin-embedded tissue samples on its InviGenius PLUS platform. The instrument uses a robotic system for a magnetic bead-based isolation of nucleic acids from 12 samples in parallel. Stratec said the method reduces hands-on time, with only 15 minutes of preparation time for loading the instrument and protocol selection. The firm believes the kit will help increase productivity and efficiency to obtain reliable test results in molecular pathology analysis.

Pages

Holden Thorp is to be the new editor-in-chief of Science and its related journals.

Adelaide University has suspended the head of an ancient DNA lab as its investigation of workplace bullying continues, Australia's ABC News reports.

A genetic analysis of salmon scales collected over the course of a century points to a sharp decline in the number of fish returning each year to river in British Columbia, CBC reports.

In PNAS this week: gene expression profiles of adipocyte subtypes, computational approach for improving plant expressome analysis, and more.