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Sep 23, 2019

Era7 V4V6 Taxonomic Profiling Service

Spanish-based Era7 has launched its V4V6 taxonomic profiling service for amplicon analysis. According to the firm, the approach uses optimal primers located in 16S regions highly conserved in bacteria and archaea. Using 300-cycle Illumina reagents, the approach sequences V4 and V6 variable regions and their flanking sequences. Era7 said that it has designed the primers to cover all sequences included in its 16SDB7 database. 

Sep 23, 2019

Streck: RNA Complete BCT

Streck has commercially launched its RNA Complete Blood Collection Tube (BCT). According to the firm, the tool maintains draw time cell-free RNA concentration while limiting the release of extracellular vesicles from blood cells. The BCT maintains the targets for up to seven days at room temperature. 

Sep 20, 2019

Toyobo RNA Analysis Kit

Toyobo of Japan is releasing RNA Analysis Kit for full-length sequencing of total RNA from a single cell. The kit is based on a method called RamDA-seq that was developed by researchers at the Laboratory for Bioinformatics Research at the Riken Center for Biosystems Dynamics Research in Japan. The method enables RNA amplification with low bias and the comprehensive identification of RNA varieties and their amounts in a single cell. The kit will officially be launched on Sept. 30.

Sep 18, 2019

Yourgene Elucigene DPYD

UK-based Yourgene has launched the Elucigene DPYD assay, a CE-marked chemotoxicity diagnostic test that uses genotyping to identify cancer patients with dihydropyrimidine dehydrogenase (DPD) deficiency. The deficiency causes several and sometimes lethal side effects in patients treated with 5-fluorouracil (5-FU), which is metabolized by the DPD enzyme, encoded by the DPYD gene. Elucigene DPYD, which tests for six common genetic variations, conforms with Clinical Pharmacogenetics Consortium guidelines, which recommend testing for four clinically relevant mutations.

Sep 17, 2019

Biognosys Spectronaut 13.7

Biognosys of Switzerland has released a new version of its Spectronaut 13 mass spectrometry analysis software. The update, version 13.7, includes beta support for the parallel accumulation-serial fragmentation (PASEF) and diaPASEF methods, which are available on Bruker's timsTOF Pro instrument.

Sep 12, 2019

Euformatics OmnomicsQ Ion Torrent Suite Plugin

Euformatics has launched the OmnomicsQ Ion Torrent Suite plugin. The software can be fully integrated with Thermo Fisher Scientific Ion Torrent sequencers to enable users to access quality control metrics and graphics as part of their workflows without the need for manual external program integration. The plugin gives Ion Torrent Suite users quality information for every sample run as part of their standard run procedure, helping to eliminate errors and flagging any issues with data quality before it affects patients, Helsinki-based Euformatics noted. In addition, the plugin enables users to perform clinical test validation of their next-generation sequencing pipelines with the OmnomicsV validation and verification software.

Sep 09, 2019

Sphere Fluidics Cyto-Cellect Human IgGk Detection Kit

Sphere Fluidics has launched its Cyto-Cellect Human IgGk Detection Kit to measure antibody class and productivity for cell line development. The FRET-based assay detects the presence of human IgG from encapsulated cells in picodroplets with kappa light chain after secretion, characterizing and measuring antibody production. According to the firm, users can combine the kit with with the Cyto-Mine Single Cell Analysis System.  

Sep 09, 2019

Fluidigm Advanta RNA-Seq NGS Library Prep Kit

Fluidigm has launched its Advanta RNA-Seq NGS Library Prep Kit, which runs on the firm's Juno microfluidic system. According to the firm, the next-generation sequencing kit allows researchers to reduce their costs for full-length stranded libraries by up to 50 percent. Fluidigm noted that the automated workflow can also reduce the number of operator interventions and total hands-on time to about two hours. The kit allows researchers to simultaneously process up to 48 samples using a integrated microfluidic circuit (IFC). By integrating solid-phase sample enrichment with sequential enzymatic reaction on the IFC, the workflow automates multiple reaction steps to product up to 48 libraries for sequencing on Illumina systems. 

Sep 05, 2019

Swift Biosciences RNA Library Kits

Swift Biosciences has launched its RNA Library Kits. With patented Adaptase technology, the kits allow direct conversion of first-strand complementary DNA, reverse transcribed from RNA, into libraries for Illumina sequencing.

The firm is offering two kits: the Swift RNA Library Kit, which supports a broad input range from as little as 10 nanograms of total RNA or 100 picograms of poly(A)-enriched messenger RNA or ribosomal RNA-depleted RNA, and the Swift Rapid RNA Library Kit, which is faster and lower-priced. Both kits are available in 24- or 96-reaction kits.

The products include an RNA fragmentation module, a reverse transcription module, library prep reagents, polymerase, and several indexing primer kit options for single, combinatorial, and unique dual indexing.

Sep 04, 2019

Xifin LIS 6

Xifin has introduced a new version of its laboratory information system, Xifin LIS 6. The latest iteration of the software-as-a-service platform includes several features resulting from recently formed partnerships. Notably, Xifin LIS 6 includes artificial intellegence-driven genomic data interpretation, thanks to a partnership with Fabric Genomics. The new release supports fast, scaleable analysis of next-generation sequencing to produce "physician-ready" clinical reports, the company said.  

Other upgrades in LIS 6 include support for digital pathology workflows via a collaboration with Proscia, integration of Glidian's automated prior authorization technology, and access to test utilization support from the Medical Database LDS laborator decsion system.

Aug 16, 2019

Integrated DNA Technologies oPools Oligo Pools

Integrated DNA Technologies has launched its oPools Oligo Pools, ready-to-use pools of high-quality DNA oligonucleotides. According to the Coralville, Iowa-based firm, the pools contain customized, single-stranded DNA sequences between 40 and 350 nucleotides in length. Because the pools are delivered in picomoles, researchers do not need to perform any pre-amplification or other pre-work before using the pool. IDT said that oPools' low error rate of less than 1 in 2,000 nucleotides, coupled with high per-oligo yields, allow researchers to immediately proceed into their downstream workflows including CRIPSR library construction, protein screening, and gene assembly.   

Aug 15, 2019

Loop Genomics LoopSeq Bacterial Genome Sequencing Kit and Services

Loop Genomics has launched a new sample preparation kit and service for de novo bacterial genome assembly using synthetic long reads on Illumina sequencers.

The LoopSeq Bacterial Genome Sequencing kit leverages the firm's chemistry and computational pipeline to create reads thousands of base pairs long, providing high-quality assemblies with fewer total contigs, higher N50 values, and fewer misassemblies.

San Jose, California-based Loop Genomics said the kit is plug-and-play and can easily replace existing sample preparation kits for bacterial genome sequencing experiments, using Loop's software for data analysis.

Aug 13, 2019

Dovetail Genomics Omni-C Assay

Dovetail Genomics has launched the Omni-C, a new assay based on the Hi-C method for chromosome conformation capture.

Scotts Valley, California-based Dovetail said it designed the assay for ease of use and improved reproducibility. The firm claims the assay offers better coverage compared to standard Hi-C approaches, by using an endonuclease, rather than restriction enzymes, to digest cross-linked chromatin.

Traditional restriction enzyme-based Hi-C approaches generate data only near the restriction enzyme sites, resulting in gaps of information. By using an endonuclease, Omni-C enables coverage of a significant portion of the genome that does not contain these restriction sites, estimated to be around 20 percent in human genomes. 

Applications for Omni-C include structural genetic variant detection and generating genome assemblies. 

Aug 09, 2019

Streck ARM-D Kits; RNA Complete BCT

Streck this week launched three new real-time PCR antibiotic resistance kits for research use only. The kits cover MCR, expanded OXA, and TEM/SHV/GES to detect variants of resistance genes considered by the US Centers for Disease Control.

Streck also introduced RNA Complete BCT, a direct-draw whole-blood collection tube containing a specially designed reagent which maintains the draw-time concentration of extracellular vesicles such as exosomes for up to 7 days at room temperature storage.

Aug 08, 2019

Novogene NovoPM 2.0 Cancer Panel

Chula Vista, California-based Novogene has launched its NovoPM 2.0 Cancer Panel, a next-generation sequencing panel that analyzes 484 solid tumor-related genes and introns in 43 genes. According to the firm, the test can detect four types of genomic abnormalities (single nucleotide variation, insertions/deletions, copy number variation, and fusions), and features bioinformatics software including three algorithms specific for guiding cancer immunotherapy decision making.

Aug 08, 2019

ChunLab TrueBac ID

Korean bioinformatics firm ChunLab has launched TrueBac ID, a cloud-based platform that combines proprietary algorithms and a manually curated reference database for bacterial identification targeting more than 12,000 species. The system can provide a full identification report within 30 minutes after a user uploads a genome assembly or raw shotgun sequencing data as a FASTQ file. The report provides fully resolved taxonomic classification, antimicrobial resistance genes, and virulence genes to facilitate correct diagnosis and appropriate therapy. In a recently published study, TrueBac ID was able to accurately identify 34 of 36 clinical isolates (94.4 percent) that were not identified using three commercially available MALDI-TOF MS systems. ChunLab said that it is providing the service for free to all users until the end of 2019 with certain restrictions. In 2020, the company plans to add functions such as strain typing to the platform.

Aug 02, 2019

Twist Bioscience Long Oligonucleotides

San Francisco-based Twist Bioscience has launched its long oligonucleotides product line. According to the firm, the synthetic nucleotides can be upto 300 bases and will increase the success and productivity of biological research. While adding bases normally introduces the risk of error, Twist said it has developed a proprietary way to make oligos with an error rate as low as 1:1500 nucleotides.

Jul 31, 2019

Mesa Biotech RSV

San Diego, California-based molecular diagnostics developer Mesa Biotech has launched a respiratory syncytial virus test on its sample-to-answer point-of-care PCR system, the Acula. The RSV test is the second test on the system, which also runs an influenza A/B test and is exclusively marketed in the US by Sekisui under the Silaris brand. It was cleared by the US Food and Drug Administration and CLIA-waived last year for diagnostic use in both children and adults.

Jul 29, 2019

GridIon Mk1

Oxford Nanopore Technologies has launched GridIon Mk1, an upgrade to the GridIon X5 sequencing platform that will start shipping this week. It contains more powerful GPU technology, specifically a Nvidia Volta GV100 card, so basecalling now only requires 10 percent of the GPU resource. In addition, power requirements have been simplified, which increases the stability of the platform.

Jul 23, 2019

BioDot Rainmaker

Irvine, California-based BioDot has launched its Rainmaker picoliter volume printing platform. According to the liquid handling company, Rainmaker allows researchers to use up to 24 independent tips to dispense volumes ranging from 20 pL to several nLs at high speed. BioDot said the tool's programmable drop size and precision controls allow users to shrink assays to improve performance and reduce costs, while optimizing for rheology or surface characteristics. 

Pages

The Los Angeles Times reports that a case of the novel coronavirus making people ill in China has been reported in the US. 

A bipartisan group of senators has introduced a bill seeking increased funding for certain fields, including synthetic biology, ScienceInsider reports. 

Discover magazine writes that paleoproteomics is increasing being used in archaeology, paleoanthropology, and paleontology, including a recent study of a 6,000-year-old ring. 

In Nucleic Acids Research this week: mutagenic effects of ultraviolet "A" light, post-transcription effects of synonymous mutations, and more.